线粒体质量控制系统失调介导帕金森病的作用机制

doi:10.3969/j.issn.1006-5725.2024.11.002

Abstract

Abstract:

Parkinson's disease （PD） is a common neurodegenerative disease with a complex pathogenesis， and a large number of studies have shown that mitochondrial dysfunction is an important causative factor for PD， whereas dysregulation of mitochondrial quality control is a key factor leading to mitochondrial dysfunction， and that aberrant mitochondrial biogenesis， fusion/fission imbalance， and mitochondrial hyperautophagy are closely associated with the onset of PD， but the role of the mitochondrial quality control system in the progression of PD is unclear. Therefore， this paper reviews the mechanism of mitochondrial quality control system in PD， with the aim of providing new ideas and theoretical basis for the clinical prevention and treatment of PD.

Key words: Parkinson's disease, mitochondrial quality control, mitochondrial biogenesis, mitochondrial dynamics, mitochondrial autophagy

CLC Number:

R742

Juan LIU,Yanjie LI,Hewei QIN,Luyao MA,Nannan ZHAO,Huimin. DING. Mechanism of action of dysregulated mitochondrial quality control system mediating Parkinson′s disease[J]. The Journal of Practical Medicine, 2024, 40(11): 1479-1482.

References 29

1	COSTA H N， ESTEVES A R， EMPADINHAS N， et al. Parkinson's Disease： A Multisystem Disorder ［J］. Neurosci Bull， 2023， 39（1）： 113-124. doi:10.1007/s12264-022-00934-6 doi: 10.1007/s12264-022-00934-6
2	耿磊，王锐，张照婷，等. 弥散张量成像对帕金森病前驱期的诊断价值［J］. 实用医学杂志， 2023， 39（21）： 2843-2849. doi:10.3969/j.issn.1006-5725.2023.21.025 doi: 10.3969/j.issn.1006-5725.2023.21.025
3	MORADI VASTEGANI S， NASROLAHI A， GHADERI S， et al. Mitochondrial Dysfunction and Parkinson's Disease： Pathogenesis and Therapeutic Strategies ［J］. Neurochem Res， 2023， 48（8）： 2285-2308. doi:10.1007/s11064-023-03904-0 doi: 10.1007/s11064-023-03904-0
4	HENRICH M T， OERTEL W H， SURMEIER D J， et al. Mitochondrial dysfunction in Parkinson's disease - a key disease hallmark with therapeutic potential ［J］. Mol Neurodegener， 2023， 18（1）： 83. doi:10.1186/s13024-023-00676-7 doi: 10.1186/s13024-023-00676-7
5	CHEN C， TURNBULL D M， REEVE A K. Mitochondrial Dysfunction in Parkinson's Disease-Cause or Consequence？［J］. Biology （Basel）， 2019， 8（2）：38. doi:10.3390/biology8020038 doi: 10.3390/biology8020038
6	CHEN C， MCDONALD D， BLAIN A， et al. Parkinson's disease neurons exhibit alterations in mitochondrial quality control proteins ［J］. NPJ Parkinsons Dis， 2023， 9（1）： 120. doi:10.1038/s41531-023-00564-3 doi: 10.1038/s41531-023-00564-3
7	TREMPE J F， GEHRING K. Structural Mechanisms of Mitochondrial Quality Control Mediated by PINK1 and Parkin ［J］. J Mol Biol， 2023， 435（12）： 168090. doi:10.1016/j.jmb.2023.168090 doi: 10.1016/j.jmb.2023.168090
8	JOHNSON J， MERCADO-AYON E， MERCADO-AYON Y， et al. Mitochondrial dysfunction in the development and progression of neurodegenerative diseases ［J］. Arch Biochem Biophys， 2021， 702： 108698. doi:10.1016/j.abb.2020.108698 doi: 10.1016/j.abb.2020.108698
9	ASGHAR M， ODEH A， FATTAHI A J， et al. Mitochondrial biogenesis， telomere length and cellular senescence in Parkinson's disease and Lewy body dementia ［J］. Sci Rep， 2022， 12（1）： 17578. doi:10.1038/s41598-022-22400-z doi: 10.1038/s41598-022-22400-z
10	PANES J D， WENDT A， RAMIREZ-MOLINA O， et al. Deciphering the role of PGC-1α in neurological disorders： from mitochondrial dysfunction to synaptic failure ［J］. Neural Regen Res， 2022， 17（2）： 237-245. doi:10.4103/1673-5374.317957 doi: 10.4103/1673-5374.317957
11	CHOONG C J， MOCHIZUKI H. Involvement of Mitochondria in Parkinson's Disease ［J］. Int J Mol Sci， 2023， 24（23）：17027. doi:10.3390/ijms242317027 doi: 10.3390/ijms242317027
12	HU Z， MAO C， WANG H， et al. CHIP protects against MPP（+）/MPTP-induced damage by regulating Drp1 in two models of Parkinson's disease ［J］. Aging （Albany NY）， 2021， 13（1）： 1458-1472. doi:10.18632/aging.202389 doi: 10.18632/aging.202389
13	CHEN J， GAO X， ZHENG C， et al. Low-dose Cu exposure enhanced α-synuclein accumulation associates with mitochondrial impairments in mice model of Parkinson's disease ［J］. Toxicol Lett， 2023， 387： 14-27. doi:10.1016/j.toxlet.2023.09.004 doi: 10.1016/j.toxlet.2023.09.004
14	GAO S， HU J. Mitochondrial Fusion： The Machineries In and Out ［J］. Trends Cell Biol， 2021， 31（1）： 62-74. doi:10.1016/j.tcb.2020.09.008 doi: 10.1016/j.tcb.2020.09.008
15	WANG X L， FENG S T， WANG Y T， et al. Mitophagy， a Form of Selective Autophagy， Plays an Essential Role in Mitochondrial Dynamics of Parkinson's Disease ［J］. Cell Mol Neurobiol， 2022， 42（5）： 1321-1339. doi:10.1007/s10571-021-01039-w doi: 10.1007/s10571-021-01039-w
16	DEHESTANI M， LIU H， SREELATHA A A K， et al. Mitochondrial and autophagy-lysosomal pathway polygenic risk scores predict Parkinson's disease ［J］. Mol Cell Neurosci， 2022， 121： 103751. doi:10.1016/j.mcn.2022.103751 doi: 10.1016/j.mcn.2022.103751
17	SOYAL S M， ZARA G， FERGER B， et al. The PPARGC1A locus and CNS-specific PGC-1α isoforms are associated with Parkinson's Disease ［J］. Neurobiol Dis， 2019， 121： 34-46. doi:10.1016/j.nbd.2018.09.016 doi: 10.1016/j.nbd.2018.09.016
18	WU P， DONG Y， CHEN J， et al. Liraglutide Regulates Mitochondrial Quality Control System Through PGC-1α in a Mouse Model of Parkinson's Disease ［J］. Neurotox Res， 2022， 40（1）： 286-297. doi:10.1007/s12640-021-00460-9 doi: 10.1007/s12640-021-00460-9
19	CARDANHO-RAMOS C， MORAIS V A. Mitochondrial Biogenesis in Neurons： How and Where ［J］. Int J Mol Sci， 2021， 22（23）：13059. doi:10.3390/ijms222313059 doi: 10.3390/ijms222313059
20	BARAZZUOL L， GIAMOGANTE F， BRINI M， et al. PINK1/Parkin Mediated Mitophagy， Ca（2+） Signalling， and ER-Mitochondria Contacts in Parkinson's Disease ［J］. Int J Mol Sci， 2020， 21（5）：1772. doi:10.3390/ijms21051772 doi: 10.3390/ijms21051772
21	QUINN P M J， MOREIRA P I， AMBRóSIO A F， et al. PINK1/PARKIN signalling in neurodegeneration and neuroinflammation ［J］. Acta Neuropathol Commun， 2020， 8（1）： 189. doi:10.1186/s40478-020-01062-w doi: 10.1186/s40478-020-01062-w
22	IMBERECHTS D， KINNART I， WAUTERS F， et al. DJ-1 is an essential downstream mediator in PINK1/parkin-dependent mitophagy ［J］. Brain， 2022， 145（12）： 4368-4384. doi:10.1093/brain/awac313 doi: 10.1093/brain/awac313
23	李若男，杨俊，张静，等. 线粒体质量控制系统在心脏衰老中的研究进展［J］. 实用医学杂志， 2023， 39（8）： 1052-1057. doi:10.3969/j.issn.1006-5725.2023.08.023 doi: 10.3969/j.issn.1006-5725.2023.08.023
24	ZHAO Y， ZHANG J， ZHENG Y， et al. NAD（+） improves cognitive function and reduces neuroinflammation by ameliorating mitochondrial damage and decreasing ROS production in chronic cerebral hypoperfusion models through Sirt1/PGC-1α pathway ［J］. J Neuroinflammation， 2021， 18（1）： 207. doi:10.1186/s12974-021-02250-8 doi: 10.1186/s12974-021-02250-8
25	BERENGUER-ESCUDER C， GROSSMANN D， ANTONY P， et al. Impaired mitochondrial-endoplasmic reticulum interaction and mitophagy in Miro1-mutant neurons in Parkinson's disease ［J］. Hum Mol Genet， 2020， 29（8）： 1353-1364. doi:10.1093/hmg/ddaa066 doi: 10.1093/hmg/ddaa066
26	MENCKE P， BOUSSAAD I， ROMANO C D， et al. The Role of DJ-1 in Cellular Metabolism and Pathophysiological Implications for Parkinson's Disease ［J］. Cells， 2021， 10（2）：347. doi:10.3390/cells10020347 doi: 10.3390/cells10020347
27	BORSCHE M， PEREIRA S L， KLEIN C， et al. Mitochondria and Parkinson's Disease： Clinical， Molecular， and Translational Aspects ［J］. J Parkinsons Dis， 2021， 11（1）： 45-60. doi:10.3233/jpd-201981 doi: 10.3233/jpd-201981
28	WANG X L， FENG S T， WANG Z Z， et al. Parkin， an E3 Ubiquitin Ligase， Plays an Essential Role in Mitochondrial Quality Control in Parkinson's Disease ［J］. Cell Mol Neurobiol， 2021， 41（7）： 1395-1411. doi:10.1007/s10571-020-00914-2 doi: 10.1007/s10571-020-00914-2
29	DOLGACHEVA L P， BEREZHNOV A V， FEDOTOVA E I， et al. Role of DJ-1 in the mechanism of pathogenesis of Parkinson's disease ［J］. J Bioenerg Biomembr， 2019， 51（3）： 175-188. doi:10.1007/s10863-019-09798-4 doi: 10.1007/s10863-019-09798-4

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Mechanism of action of dysregulated mitochondrial quality control system mediating Parkinson′s disease

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