Abstract:

Objective To investigate the effects of prealbumin on anxiety，hypersensitive C ⁃ reactive protein and lymphocytes in patients with COVID⁃19，and to provide reference for preventing COVID⁃19 and im⁃ proving its recovery. Methods The anxiety of 212 patients with COVID⁃19 was measured by Hospital Anxiety and Depression Scale（HADS），and serum prealbumin，high⁃sensitivity C⁃reactive protein and lymphocyte cells were detected by the hospital laboratory. Results A total of 212 people，aged 19⁃59 years，were enrolled in this study， including 139 men，with an average age of 34.67 ± 9.97 years. The length of hospitalization was 2 ~ 27 days. One hundred and eight people（50.9%）were infected with COVID⁃19，71 of which（33.5%）was with novel coronavirus pneumonia（mild），and 33 people（15.6%）with novel coronavirus pneumonia（common）. Serum prealbumin was negatively correlated with anxiety（P < 0.001）and the level of high⁃sensitivity C⁃reactive protein，and positively with the number of lymphocytes（P < 0.001）. Anxiety was negatively correlated with lymphocytes（P < 0.01），and hypersensitive C⁃reactive protein was negatively correlated with lymphocytes as well（P < 0.001）. The mediating effect consisted of two paths：the indirect effect 1 of prealbumin→anxiety→lymphocytes and the indirect effect 2 of prealbumin→hs ⁃ CRP→lymphocytes. The results showed that prealbumin could affect lymphocytes through the mediation of anxiety and hs ⁃CRP（P < 0.05）. Conclusion Prealbumin exerts influence on lymphocytes through the importantly mediating role of anxiety and hypersensitive C⁃reactive protein in patients with COVID⁃19 infection.

Key words:

people infected with novel coronavirus, prealbumin, anxiety, hypersensitive C?reactive protein, lymphocyte