Abstract:

Objective To investigate the characteristics of the patients with multidrug⁃resistant pulmonary tuberculosis（MDR ⁃ PTB）and analyze the risk factors for developing the resistance of fluoroquinolones（FQs）. Methods A total of 230 MDR ⁃PTB patients admitted to Anhui Chest Hospital from April 2019 to March 2021 were collected and divided into the FQs sensitive group and the FQs resistant group according to the type of drug resistance. The chi ⁃ square test was used for comparative analysis of the factors related to FQs resistance，and multivariate logistic regression analysis was conducted to screen out independent risk factors. Results The chi ⁃ square test showed the risk factors related to FQs resistance were the type of treatment，the use of second⁃line anti⁃ tuberculosis drugs previously，comorbidities，chest CT findings，body mass index（BMI）and age（P < 0.05 for all）. Multivariate logistic regression analysis showed the use of second⁃line anti⁃tuberculosis drugs previously and BMI < 18.5 kg/m2 were independent risk factors（P < 0.05 for both）. Conclusion The use of second⁃line anti⁃tuberculosis drugs previously and BMI < 18.5 kg/m2 are independent risk factors for developing FQs drug resistance in MDR ⁃ PTB patients，which has certain reference value for clinical rapid diagnosis and differential diagnosis of FQs resis⁃ tant tuberculosis.

Key words:

tuberculosis, multidrug?resistant pulmonary tuberculosis, fluoroquinolones, fisk factors