Abstract:

Objective To explore the related influencing factors of sub⁃delirium syndrome in patients with severe tumor，and to construct a drug⁃free therapy and then to analyze its application value. Methods A total of 286 patients with severe tumor who were hospitalized from September 2020 to March 2021 were used as study subjects. They were screened for sub ⁃ delirium and divided into a sub ⁃ delirium group（SSD group，n = 172）and a group without sub⁃delirium（non⁃SSD，n = 114）. The general data onthe patients were collected，and the univariate and multivariate analysis were applied to analyze the related risk factors. Based onthe analysis results，a drug ⁃free treatment plan for sub ⁃delirium syndrome was constructed. The sub ⁃delirium group weresubdivided into a routine plan intervention group（control group）and a drug⁃free treatment plan intervention group（study group）by using a random number table The incidence of delirium，total dailyhours ofsleep after intervention，hospital stay，sleep quality score，cognitive function score，VAS score，HAMA score，APACHEⅡscore and PPI score were compared between the two groups. The application value was analyzed. Results The rate of sub⁃delirium was 60.13% in 286 patients. The scores on ECOG，APACHEⅡ，and PPI were higher in the SSD group than in the non ⁃SSD group （P < 0.05）. Opioids，sleep disorder，infection，PPI score and APACHEⅡscore were the independent risk factors for sub⁃delirium in patients with severe tumor（P < 0.05）. After drug⁃freetreatment，thescores oncognitive function and sleep quality and the total daily hours ofsleep were significantly higherin the study groupthan inthe control group， whilehospital stay was shorter（P < 0.05）. Thescores on VAS，HAMA，APACHEⅡand PPI were significantly lower in the study group than in the control group（P < 0.05）. The incidence rate of deliriumwas significantly lowerin the study group than in the control group（15.12% vs. 31.40%，P < 0.05）. Conclusions Opioid drugs，sleep disorder，infection，PPI score and APACHE score are independent predictors of sub⁃delirium syndrome in patients with severe tumor. The drug⁃freetreatment protocol constructed based on the results of risk analysis can significantly improve cognitive function，sleep quality，VAS score，PPI score and APACHE score，shorten hospital stay，and reduce the incidence of sub⁃delirium. It shows higher clinical application value.

Key words:

severe tumor, sub?delirium syndrome, drug?free therapy plans