Abstract:

Objective The evaluation criteria for the rational use of vonoprazan is established，in order to provide a reference for clinical rational drug use. Methods Based on the drug instructions of vonoprazan，clinical guidelines，and expert consensus，the evaluation standards for vonoprazan are formulated.AHP method was used to assign weights to various indexes of evaluation criteria. TOPSIS method was used to analyze the use of vonoprazan of 236 cases in the hospital from January 2021 to January 2022 and evaluate rational drug use. Logistic binary regression model was constructed to explore the influencing factors of irrational drug use，and through the OpenVigiL database to mine the adverse reactions of the drug after the market. Results Among 236 cases，there were 71 rea⁃ sonable cases（30.1%），1 basic reasonable case（0.4%），and 164 unreasonable cases（69.5%）.Logistic regression analysis found that concomitant use of antiplatelet drugs was the main reason for the increase in irrational drug use. In addition，a total of 88 adverse reactions of the drug were discovered. Conclusion The AHP ⁃TOPSIS method can be used to evaluate the rationality of vonorasen. The research results show that the drug has unreasonable phe⁃ nomena such as unsuitable indications，no economic considerations，and no patient education. At the same time， attention should also be paid to the adverse reactions of the drug. Intensify management efforts to promote clinical rational drug use.

Key words:

vonoprazan, AHP method, TOPSIS method, logistic binary regression, open vigiL database