Abstract:

Objective To investigate the effect of MACBAR of sevoflurane in patients with different classi⁃ fications of burn. Methods Sixty severely burned patients admitted to our hospital from June 2017 to May 2019 were divided into group A with second⁃degree burns（30%，n = 20），group B with third⁃degree burn（50%，n = 20） and group C with fourth⁃degree burn（70%，n = 20）. Three groups were given sevoflurane anesthesia induction； the MACBAR of sevoflurane was determined by sequential method，and the preoperative，intraoperative，postoper⁃ ative heart rate（HR），mean arterial pressure（MAP），blood glucose，norepinephrine，bispectral index（BIS）， disappearance time of spontaneous breathing，awakening time，extubation time and sedation ⁃agitation scale were compared. Results The MACBAR，preoperative，intraoperative，postoperative HR，MAP，blood glucos，and nor⁃ epinephrine in group C were higher than those in group B and A，and higher in group B than in group A（P < 0.05）. Disappearance time of spontaneous breathing in group C was longer than that in group B and A，and longer in group B than in group A（P < 0.05）. Awakening time and extubation time in group C were shorter than those in group B and A，and shorter in group B than in group A（P < 0.05）. There was no difference in postoperative seda⁃ tion⁃ agitation scores among the three groups（P > 0.05）. Conclusion With the severity of burn，the MACBAR of sevoflurane was increased but the anaesthetic effect time was shortened. The concentration of inhalation should be appropriately increased and drug maintenance time should be extended in the relevant surgical anesthesia

Key words:

different degrees of burn, sevoflurane, anesthesia induction, autonomous respiration, recovery of consciousness