Abstract:

Objective To evaluate the clinical value of low⁃dose dexmedetomidine（DEX）in alcoholic patients undergoing painless gastrointestinal endoscopy. Methods A total of 154 alcoholism who underwent painless gastroenteroscopy in the Affiliated Hospital of Xuzhou Medical University from July 2018 to June 2020 who met the inclusion criteria were selected. All patients were randomly divided into dexmedetomidine + propofol group（trial group）and placebo+propofol group（control group）with 77 patients in each group. Patients in the trial group were given dexmedetomidine with 0.3 μg/kg，injected through micro⁃infusion pump 10 min before anesthesia，and then given intravenous propofol with 1.5 mg/kg. The patients in the control group were given the same amount of 0.9 % sodium chloride，and the injection method of propofol was the same as that in the trial group. During the operation， the bispectral index（BIS）of the two groups was maintained between 50 to 60. The mean pulse oxygen saturation （SpO2），mean arterial pressure（MAP），heart rate（HR），respiratory rate（RR），end ⁃expiratory carbon dioxide partial pressure（PETCO2），propofol dosage，induction time，examination time，recovery time，discharge time， incidence of body movement，the satisfaction of endoscopic physicians，the satisfaction of patients and adverse reac⁃ tions were recorded. Results The mean SpO2 and the satisfaction of endoscopic physicians in the trial group were significantly higher than those in the control group，while the dosage of propofol，induction time，awakening time， discharge time and the incidence of physical reaction in the trial group were significantly lower than those in the control group（P＜0.05）. There was no significant difference in examination time and patient satisfaction between the two groups. Discussion Low⁃dose dexmetomidine is safe and effective in painless gastroenteroscopy in patients with alcoholism，which can improve the sedative effect and reduce the occurrence of adverse events.

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