Abstract:

Objective To compare the effectiveness of long⁃effect and short⁃effect granulocyte colonystimulating factor（G⁃CSF）in treatment of bone marrow suppression induced by multi⁃cycle chemotherapy for malig⁃nancies. Methods A retrospective analysis was conducted for 117 cases who used granulocyte colony stimulatingfactor to prevent and treat bone marrow suppression induced by chemotherapy for advanced malignancies in theThird Affiliated Hospital of Zunyi Medical University during Jul. 2019 to Feb. 2020. Among them，54 cases weretreated with Recombinant human granulocyte colony stimulating factor injection（short⁃effect，rhG⁃CSF group），and 63 cases were treated with Polyethylene glycol recombinant human granulocyte stimulating factor injection（long⁃effect，PEG⁃rhG⁃CSF group）. Clinical efficacies，the occurrence of bone marrow suppression and ADR werecompared between 2 groups. Results Patients in both groups showed different degrees of bone marrow suppressionafter chemotherapy，the time of WBC/ANC return to the normal range in the PEG⁃rhG⁃CSF group was（3.53 ±1.38）days，which was shorter than that in the rhG⁃CSF group（4.52 ± 1.78） days（P < 0.05）. And the maintenancetime after WBC/ANC rose to the normal range was（11.07 ± 2.98）days in the PEG⁃rhG⁃CSF group and（6.04 ±2.43）days in the rhG⁃CSF group respectively，which has a statistical difference between the two groups（P < 0.01）.After 3 days of G⁃CSF treatment，59.20% of patients in the rhG⁃CSF group returned to the normal range in WBC/ANC counts，compared with 69.80% in the PEG⁃rhG⁃CSF group. Conclusions Both rhG⁃CSF and PEG⁃rhG⁃CSFhad beneficial therapeutic effects on bone marrow suppression caused by multiple cycles of chemotherapy inpatients with malignant tumors，and the recovery of WBC/ANC in the PEG⁃rhG⁃CSF group was superior to that in the rhG⁃CSF group.

Key words: recombinant human granulocyte colony stimulating factor, polyethylene glycol recombinant human granulocyte stimulating factor, malignancies, multi?cycle chemotherapy, bone marrow suppression