关键词:

双膦酸盐, 骨质疏松症, 临床疗效, 不良反应, 药物假期

Abstract:

Osteoporosis is a systemic metabolic disease. Bisphosphonates are the first ⁃line drugs in the treatment of osteoporosis，which have been proved to have significant effects on improving bone density and reduc⁃ ing the risk of fracture. This article systematically reviewed the mechanism of action，clinical efficacy，adverse reactions and drug holiday of several bisphosphonates，which might provide useful information for future research.

Key words:

bisphosphonates, osteoporosis, clinical efficacy, adverse reactions, drug holiday