关键词:

HR?HPV, HR?HPV 亚型, 农村妇女, 青藏高原

Abstract:

Objective The existing research data lacks the HR ⁃HPV infection status and HR ⁃HP Vsubtype distribution of females in rural areas of Linzhi City，Tibet. This study intended to improve the domesticHR ⁃ HPV epidemiological data，inspire domestic HPV vaccine research and solve the above problem. Methods The results of two⁃cancer screening in rural women in Linzhi City，Tibet from 2019 to the first quarters of 2021were collected. PCR fluorescence were applied to detect HR ⁃HPV subtype genes in the screened specimens. Westatistically analyze HPV infection in rural women in Linzhi City，Tibet. The infection rate of different HR ⁃HPV subtypes and the infection rate of HR⁃HPV subtypes in different age groups were compared with others in ruralareas outside the Qinghai ⁃Tibet Plateau. The infection rate of different HR ⁃HPV subtypes were also analysed.Results A total of 13 741 cases were included in the study. The overall HR⁃HPV infection rate of women in ruralareas of Linzhi City，Tibet was 12.81%（1 760/13 741），which was higher than that of women in rural areas out⁃side the Qinghai⁃Tibet Plateau（7.82%，9 249/118 237）（χ2 = 532.2，P < 0.001）. The 35 ~ 39 years old group had the highest HPV infection rate（14.99%，441/2 942）which was higher than that of women in the same agegroup in rural areas outside the Qinghai⁃Tibet Plateau（7.22%，1 827/25 322）（χ2 = 215.9，P < 0.001）. The 50 ~54 years old group has the lowest HPV infection rate，9.47%（209/2 208），and 8.14%（1 604/19 698）of HPV infec⁃tion rate of women in the same age group outside the Qinghai ⁃ Tibet Plateau，which was no statistical difference（χ2 = 4.575，P = 0.032）. The top three subtypes of HR⁃HPV infection among women in rural areas of Linzhi City，Tibet are HPV52（19.94%，351/1 760），HPV16（12.33%，217/1 760）and HPV58（11.88%，209/1 760）. Thetop three HR⁃HPV infection subtypes of women in rural areas outside the plateau were consistent with the HR⁃HPVinfection subtypes of rural women in Linzhi City，Tibet. The top three HR⁃HPV subtypes of women in the 35 ~ 39，40 ~ 44，and 45 ~ 49 age groups in rural areas of Linzhi City，Tibet are HPV52，HPV16，and HPV58 respectively，which were similar to those on the rural areas outside Qinghai⁃Tibet Plateau. Conclusion The HR⁃HPV infectionrate of women in rural areas of Linzhi City，Tibet was significantly higher than that of women in rural areas outsidethe Qinghai⁃Tibet Plateau. The top three HR⁃HPV infection subtypes in two regions were the same.

Key words:

HR?HPV, HR?HPV subtypes, rural women, Qinghai?Tibet plateau