实用医学杂志 ›› 2021, Vol. 37 ›› Issue (18): 2391-2394.doi: 10.3969/j.issn.1006⁃5725.2021.18.017

• 临床研究 • 上一篇    下一篇

载脂蛋白E和MTHFR C677T基因多态性与精神分裂症及患者认知功能的关联性

李佳1 林荫2 吉训琦3 康延海1 董洁1   

  1. 海南省人民医院1 精神心理科,3 儿科(海口 570000);2 海南省安宁医院心理咨询与治疗中心 (海口 570206)

  • 出版日期:2021-09-25 发布日期:2021-09-25
  • 通讯作者: 吉训琦 E⁃mail:jxq4223@163.com
  • 基金资助:

    海南省卫生计生行业科研项目(编号:19A200061)


Association of APOE and MTHFR C677T gene polymorphisms with schizophrenia and cognitive function in patients

LI Jia*,LIN Yin,JI Xunqi,KANG Yanhai,DONG Jie.   

  1. Department of Psychiatry,Hainan Provin⁃ cial People′s Hospital,Haikou 570000,China

  • Online:2021-09-25 Published:2021-09-25
  • Contact: JI Xunqi E⁃mail:jxq4223@163.com

摘要:

目的 研究载脂蛋白 E(ApoE)和 MTHFR C677T 基因多态性与精神分裂症患病及患者认知功能的关联。方法 收集 2018 年 1 月 1 日至 2020 年 1 月 1 日海南省人民医院和海南省安宁医院诊治的精 神分裂症患者 84 例及同期于海南省人民医院体检健康者 84 例为研究对象,检测 ApoE 和 MTHFR C677T 的 基因型及认知功能,行相关性分析。结果 ApoE 基因型与精神分裂症无关(> 0.05);MTHFR C677T 基 因型与精神分裂症有关(< 0.05),对照组基因以 CT(50%)为主,病例组基因以 TT(36.47)及 CT(45.23%) 为主(< 0.05);认知功能的指标评分与精神分裂症有关(< 0.05);ApoE 基因型与研究对象的认知功能 无关,MTHFR C677T 基因型与研究对象的认知功能相关(< 0.05)。结论 ApoE 基因多态性与患精神分 裂症以及认知功能无相关性,MTHFR C677T基因多态性与患精神分裂症以及认知功能有相关性。

关键词: 精神分裂症,  , 认知功能,  , 载脂蛋白E,  , 亚甲基四氢叶酸还原酶,  , 基因多态性

Abstract:

Objective To investigate the association of ApoE and MTHFR C677T gene polymorphisms with schizophrenia and cognitive function. Methods A total of 84 schizophrenic patients who were admitted to Hainan Provincial People′s Hospital and Anning Hospital from January 1,2018 to January 1,2020 and 84 healthy subjects who were admitted to Hainan Provincial People′s Hospital during the same period were collected. The geno⁃ types and cognitive function of ApoE and MTHFR C677T were detected and the correlation analysis was performed. Results APOE genotype was not associated with schizophrenia(P > 0.05). The MTHFR C677T genotype was associated with schizophrenia(P < 0.05). The genotype was mainly CT(50%)in the control group,whereas was mainly TT(36.47)and CT(45.23%)in the study group(P < 0.05). The index score of cognitive function was related to schizophrenia(P < 0.05). APOE genotype was not associated with cognitive function,while MTHFR C677T genotype was associated with cognitive function(P < 0.05). Conclusions APOE gene polymorphism is not associated with schizophrenia and cognitive function,while MTHFR C677T gene polymorphism is related with schizophrenia and cognitive function.

Key words:

schizophrenia, cognitive function, apolipoprotein e, methylenetetrahydrofolate reduc? tase, gene polymorphism