实用医学杂志 ›› 2021, Vol. 37 ›› Issue (13): 1711-1718.doi: 10.3969/j.issn.1006⁃5725.2021.13.013

• 临床研究 • 上一篇    下一篇

残余胆固醇水平对急性脑梗死发病的预测价值

聂大奥1, 林桥文2, 谭文惠1, 李扬锋2, 黄建鑫2    

  1. 1 广东省第二人民医院神经内科(广州 510317);2 乳源县人民医院内科(广东韶关 512700)

  • 出版日期:2021-07-10 发布日期:2021-07-10
  • 通讯作者: 林桥文 E⁃mail:1726908904@qq.com
  • 基金资助:

    广东省医学科研基金(编号:2021009


The predictive value of remnant cholesterol level in patients with acute cerebral infarction 

NIE Daao LIN QiaowenTAN WenhuiLI YangfengHUANG Jianxin.    

  1. Department of Neurology,the Second People′s Hospital of Guangdong Province,Guangzhou 510317,China 

  • Online:2021-07-10 Published:2021-07-10
  • Contact: LIN Qiaowen E⁃mail:1726908904@qq.com

摘要:

目的 探讨残余胆固醇(remnant cholesterol,RC)水平对急性脑梗死(acute cerebral infarction ACI)发病的预测价值。方法 选取乳源县人民医院 2020 1-12 月首诊于我院的 ACI 患者 120例为病例组。选取同期120例健康体检者作为对照组。利用相关性分析及绘制ROC曲线的方式分析残余胆固醇、总胆固醇(total cholesterol,TC)、低密度脂蛋白胆固醇(low⁃density lipoprotein cholesterol,LDL⁃C)、高密度脂蛋白 胆固醇(high⁃density lipoprotein cholesterol,HDL⁃C)、非高密度脂蛋白胆固醇(non⁃high density lipoprotein cholesterol,non⁃HDL⁃C)水平对 ACI 发病的预测价值。结果 ACI LDL⁃C、HDL⁃C、RC non⁃HDL⁃C 水平 显著高于对照组,差异有统计学意义(P<0.05),而两组间 TC 水平差异无统计学意义(P>0.05)。多因素 logistic 回归分析表明:TC、LDL⁃C、HDL⁃C、RC non⁃HDL⁃C 均为 ACI 发生的危险因素。ROC 分析显示,相较于其他指标,RC 的水平对于 ACI 的发生具有更好的预测价值。结论 RC 对于 ACI 的发病有一定预测 诊断价值。

关键词:

急性脑梗死, 血脂, 残余胆固醇, 非高密度脂蛋白胆固醇

Abstract:

Objective To investigate the predictive value of remnant cholesterol(RC)level in patients with acute cerebral infarction(ACI). Methods A total of 120 patients with ACI who were first diagnosed in our hospital from January 2020 to December 2020 in Ruyuan County People′s Hospital were selected as the research group. 120 healthy subjects during the same period were selected as the control group. The levels of RC,total cho⁃ lesterol(TC),low⁃density lipoprotein cholesterol(LDL⁃C),high⁃density lipoprotein cholesterol(HDL⁃C)and non⁃ high density lipoprotein cholesterol(non⁃HDL⁃C)were analyzed by correlation analysis and ROC curve to evaluate the predictive value on the incidence of ACI. Results The levels of LDL⁃C,HDL⁃C,RC,and non⁃HDL⁃C in the research group were significantly higher than those in the healthy control group,and the difference was statistically significant(P < 0.05). Between the two groups,there is no significant statistical difference in TC levels(P > 0.05). Logistic multivariate regression analysis showed that TC,LDL⁃C,HDL⁃C,RC and non⁃HDL⁃C are all risk factors for ACI. Compared with other indicators,further ROC analysis showed that the level of RC has a better predictive value for the occurrence of ACI. Conclusion RC has certain predictive and diagnostic value for the onset of ACI. 

Key words:

acute cerebral infarction, blood lipids, residual cholesterol, non?high?density lipopro-tein cholesterol