实用医学杂志 ›› 2020, Vol. 36 ›› Issue (23): 3297-3300.doi: 10.3969/j.issn.1006⁃5725.2020.23.027

• 中医药现代化 • 上一篇    下一篇

三焦次第疗法治疗慢性心力衰竭的效果及对神经内分泌激素活性的影响

陈炜, 胡跃强, 吴林, 王庆高, 罗试计, 黄家兴, 谢岚君   

  1. 广西中医药大学第一附属医院1脑病一区,3心内一区(南宁530023);2 广西中医药大学中医药科学实验中心(南宁530001);4百色市中医医院心血管科(广西百色533000);5龙州县中医医院脑病科(广西崇左532400)

  • 出版日期:2020-12-10 发布日期:2020-12-23
  • 通讯作者: 吴林E⁃mail:15177775008@139.com
  • 基金资助:

    国家自然科学基金(编号:81760847);广西科技计划项目重点研发计划(编号:AB16380324);广西中医基础研究重点实验室系统课题(编号:16⁃380⁃58⁃06);广西中医药大学岐黄工程高层次人才团队培育项目(编号:2018003);广西中医药大学第一附属医院学术团队[编号:院字2018(146)号]

Effect of Sanjiao Regular Sequence Therapy on chronic heart failure and its effect on neuroendocrine hor⁃mone activity

CHEN Wei,HU Yueqiang,WU Lin,WANG Qinggao,LUO Shiji,HUANG Jiaxing,XIE Lanjun.   

  1. Department of Encephalopathy,the First Affiliated Hospital of Guangxi University of Chinese Medicine,Nanning 530023,China
  • Online:2020-12-10 Published:2020-12-23
  • Contact: WU Lin E⁃mail:15177775008@139.com

摘要:

目的 探讨三焦次第疗法治疗慢性心力衰竭的效果及对神经内分泌激素活性的影响。方法 2019年1月至2020年1月多中心收治的200例CHF患者,采用随机分配方案分为对照组(n = 100,予以常规治疗)和治疗组(n = 100,在对照组基础上联合三焦次第疗法),比较两组患者治疗前后LHFQ评分、6 min步行试验(6MWT)距离、左室射血分数(LVEF)、脑利钠肽前体(NT⁃proBNP)、血管紧张素Ⅱ(Ang⁃Ⅱ)水平,并评估两组的中医证候积分疗效。结果 治疗组、对照组的有效率分别为82.00%、68.00%,组间差异有统计学意义(Z = 2.439,P < 0.05)。经过治疗后,两组的LHFQ评分、NT⁃proBNP、Ang⁃Ⅱ降低(P < 0.05),其6 min步行距离、LVEF高(P < 0.05),且治疗组治疗后的LHFQ评分、NT⁃proBNP、Ang⁃Ⅱ水平低于对照组(P < 0.05),其6 min步行距离、LVEF升高于对照组(P < 0.05)。结论 三焦次第疗法治疗慢性心力衰竭的效果显著,能提高生活质量,增加运动耐量,降低NT⁃proBNP、Ang⁃Ⅱ等神经内分泌激素活性,抑制心室重构,促进心功能的改善。

关键词: 三焦次第疗法, 慢性心力衰竭, 脑利钠肽前体, 心功能, 血管紧张素Ⅱ, 生活质量

Abstract:

Objective To investigate the effect of Sanjiao Regular Sequence Therapy on chronic heartfailure and its effect on neuroendocrine hormone activity. Methods In January 2019 ⁃ January 2020 at the recordsof 200 patients with CHF,multicenter randomized allocation scheme were divided into control group(n = 100 cases,with regular treatment)and treatment group(n = 100 cases,Sanjiao Regular Sequence Therapy based on the controlgroup),LHFQ score,6 min walking distance test(6 MWT),left ventricular ejection fraction(LVEF),brainnatriuretic peptide precursor(NT⁃proBNP),angiotensin Ⅱ(AngⅡ)level before treatment and after treatmentwere compared between two groups,and the curative effect of TCM syndrome integral of the two groups wereassessed. Results The effective rate was 82.00% in the treatment group and 68.00% in the control group,and thedifference between the groups was statistically significant(Z = 2.439,P < 0.05). After treatment,the LHFQscore,nt⁃probnp and ang⁃ii in the two groups decreased(P < 0.05),and the LHFQ score,NT⁃proBNP and ang⁃iiin the treatment group were lower than those in the control group(P < 0.05),and the LVEF in the 6 min walkingdistance and LVEF in the treatment group were higher than those in the control group(P < 0.05). Conclusion The treatment of chronic heart failure with three⁃focal therapy has a significant effect ,which can significantlyimprove the quality of life,increase the exercise tolerance,reduce the activities of NT⁃proBNP,Ang⁃Ⅱ and otherneuroendocrine hormones,inhibit ventricular remodeling,and promote the improvement of cardiac function.

Key words: Sanjiao Regular Sequence Therapy, chronic heart failure, brain natriuretic peptide pre?cursor, cardiac function, angiotensin Ⅱ, quality of life