实用医学杂志 ›› 2022, Vol. 38 ›› Issue (13): 1671-1675.doi: 10.3969/j.issn.1006⁃5725.2022.13.020

• 药物与临床 • 上一篇    下一篇

肾衰宁片联合左卡尼汀对慢性肾脏病3⁃4期患者的疗效

陈杰彬1 胡蓉2 李成杰1 吕佩佳1 魏连波3    

  1. 1 南方医科大学中西医结合医院肾病科(广州 510315);2 南方医科大学中医药学院中医内科 (广州 510515);3 南方医科大学深圳医院中医科(广东深圳 518000)

  • 出版日期:2022-07-10 发布日期:2022-07-10
  • 通讯作者: 魏连波 E⁃mail:weilianbo@163.com
  • 基金资助:
    国家自然青年科学基金项目(编号:82104795)

Effect of renal attenin capsule combined with levkanetine on RBP4 and BMP⁃7 in patients with stage 3 to 4 chronic kidney disease

CHEN Jiebin*,HU Rong,LI Chengjie,LÜ Peijia,WEI Lianbo.   

  1. Department of Nephrol⁃ ogy,the Integrated Traditional Chinese and Western Medicine Hospital,Southern Medical University,Guangzhou 510315,China

  • Online:2022-07-10 Published:2022-07-10
  • Contact: WEI Lianbo E⁃mail:weilianbo@163.com

摘要:

目的 探究肾衰宁片联合左卡尼汀对慢性肾脏病 3-4 期患者的疗效。方法 随机选取我院 2019 1 月至 2021 1 月接诊的慢性肾脏病患者 100 例,数字表法分为对照组 50 例,观察组 50 例。两组 治疗 12 周后,对比两组患者疾病转归情况,测定白细胞介素⁃17(IL⁃17)、γ 干扰素(INFγ)、超敏 C⁃反应蛋白 hs⁃CRP)、视黄醇结合蛋 4(RBP4)、骨形态发生蛋白⁃7(BMP⁃7)、血清胱抑素⁃C(Cys⁃C)、血尿素氮(BUN)、 血肌酐(SCr)、丙二醛(MDA)、谷胱甘肽过氧化物酶(GSH⁃Px)、超氧化物歧化酶(SOD)、24 h 尿蛋白定量 24 h UTP)水平,分析临床疗效。结果 治疗后,与对照组相比,观察组 IL⁃17、s⁃CRP、IFN⁃γ、MDA、RBP4 Cys⁃C、24 h UTP、BUN、SCr 水平降低(P < 0.05);GSH⁃Px、SOD、BMP⁃7 水平升高(P < 0.05)。结论 肾衰宁 片联合左卡尼汀治疗慢性肾脏病可使患者肾功能缓慢恢复,减轻机体的氧化应激反应及肾脏微炎症,并 对肾脏功能恢复疗效明显。

关键词:

肾衰宁片, 左卡尼汀, 慢性肾脏病, 视黄醇结合蛋白4, 骨形态发生蛋白?7

Abstract:

Objective To explore the effect of renal attenin capsule combined with levkanetine on RBP4 and BMP⁃7 in patients with stage 3 to 4 chronic renal disease. Methods A total of 100 patients with chronic kidney disease hospitalized in our hospital from January 2019 to January 2021 were randomly selected and equally divided into control groups and observation group by the digital table method. After 14 d treatment,the two groups were compared in terms of the levels of interleukin⁃17(IL⁃17),hypersensitive C⁃reactive protein(hs⁃CRP),interferon (INFγ),retinol⁃binding protein 4(RBP4),bone morphogenesis protein⁃7(BMP⁃7),serum cystatin⁃C(Cys⁃C), blood urea nitrogen(BUN),blood creatinine(SCr),maldialaldehyde(MDA),glutathione⁃peroxidase(GSH⁃Px), superoxide dismutase(SOD),and 24 h urinary protein quantification(24 h UTP). Results After treatment,the levels of IL⁃17,s⁃CRP and IFNγ,MDA,RBP4,Cys⁃C,24 h UTP ,BUN and SCr of the observation group were significantly lowered(P < 0.05),and the levels of GSH ⁃Px,SOD and BMP ⁃7 were significantly elevated(P < 0.05),as compared with the control group. Conclusion Renal attenin capsule combined with levkanitine kidney disease can enhance slow recovery of kidney function of patients with stage 3 to 4 chronic renal disease by reducing the oxidative stress and renal microinflammation. 

Key words:

renal attenin capsule, levkanetine, chronic kidney disease, retinol?binding protein 4, bone morphogenetic protein?7