实用医学杂志 ›› 2022, Vol. 38 ›› Issue (13): 1614-1617.doi: 10.3969/j.issn.1006⁃5725.2022.13.009

• 专家笔谈 • 上一篇    下一篇

应用加味百合固金汤治疗肺结核患者的临床效果观察

潘静洁 刘堂营 黄晋 黄婷婷    

  1. Guangzhou Chest Hospital，Guangzhou 510095，China

  • 出版日期:2022-07-10 发布日期:2022-07-10
  • 基金资助:
    广东省中医药科技项目（编号：20211304）；广州市中医药和中西医结合科技项目（编号：20212A011016）

Observation of clinical effect of modified Baihe Gujin decoction in the treatment of pulmonary tuberculosis patients

PAN Jingjie，LIU Tangying，HUANG Jin，HUANG Tingting.   

  1. 广州市胸科医院中医科（广州 510095）

  • Online:2022-07-10 Published:2022-07-10

摘要：

目的 了解加味百合固金汤治疗对肺结核患者呼吸与全身症状、体征的改善情况，为结核病多学科治疗提供循证依据。方法 以 2018 年 6 月至 2021 年 12 月来我院就诊的 92 例初治肺结核患者为 研究对象，对观察组 50 例和对照组 42 例患者分别进行抗结核治疗、抗结核+加味百合固金汤（前 4 周）治 疗，观察治疗开始时和治疗第 4 周末患者咳嗽、咳嗽、咳痰、咽痛、胸闷、气短、口渴、神疲、乏力和纳呆等症 状、体征在无、轻度、中度、重度 4 种程度间的变化情况，并应用 c2 检验比较分析观察组和对照组之间以及 观察组男女性别间好转率的差异。结果 观察组咳嗽、咳痰、咽痛、胸闷、气短、口渴、神疲、乏力、纳呆和 总体好转率分别为 100%、100%、92.00%、90.00%、78.00%、96.00%、84.00%、76.00%、96.00%、90.22%，对照 组分别为 83.33%、90.48%、76.19%、45.24%、869.05%、71.43%、59.52%、64.29%、64.29%、69.31%，除咳痰、气 短、乏力外两者间率的比较均有统计学意义（P < 0.05）。观察组 24 例男性与 26 例女性之间比较，男性之 好转率分别为 100%、100%、95.83%、91.67%、75.00%、100%、91.67%、83.33%、91.67%、92.13%，女性则分 别为 100%、100%、88.46%、88.46%、80.77%、92.31%、76.92%、69.23%、100%、88.46%，两者间率的比较均无 统计学意义（P > 0.05）。结论 加味百合固金汤治疗对肺结核患者呼吸与全身症状、体征的改善明显，男 女皆宜。

关键词: 肺结核,  , 抗结核化疗,  , 加味百合固金汤,  , 症状与体征

Abstract:

Objective To understand the improvement of respiratory and systemic symptoms and signs of pulmonary tuberculosis patients treated with modified Baihe Gujin decoction，and to provide evidence ⁃ based evidence for multidisciplinary treatment of tuberculosis. Methods A total of 92 patients with newly diagnosed pulmonary tuberculosis who came to our hospital from June 2018 to December 2021 were selected as the research objects. 50 patients in the observation group and 42 patients in the control group were treated for 4 weeks with anti ⁃tuberculosis treatment and anti ⁃tuberculosis combined with modified Baihe Gujin decoction. The changes of symptoms and signs such as cough，expectoration，sore throat，chest tightness，shortness of breath，thirst，mental fatigue，fatigue and anorexia were observed before and after 4 weeks treatment，and the severity was recorded as none，mild，moderate and severe. Changes were analyzed，and the c2 test was used to compare and analyze the difference in improvement rate between the observation group and the control group，as well as between male and female in the observation group. Results The rates of cough，expectoration，sore throat，chest tightness，shortness of breath，thirst，mental fatigue，fatigue，anorexia and overall improvement in the observation group were 100%， 100%，92.00%，90.00%，78.00%，96.00%，84.00%，76.00%，96.00%，and 90.22%，respectively. The control group were 83.33%，90.48%，76.19%，45.24%，69.05%，71.43%，59.52%，64.29%，64.29%，69.31%，respectively. Except for expectoration，shortness of breath and fatigue，the comparison of the rates between the observation group and the control group was statistically significant（P < 0.05）. Comparing 24 males and 26 females in the observation group，the improvement rates for males were 100% ，100% ，95.83% ，91.67% ，75.00% ，100% ， 91.67%，83.33%，91.67%，and 92.13%，respectively. For females，the rates were 100%，100%，88.46%，88.46%， 80.77%，92.31%，76.92%，69.23%，100%，and 88.46%，respectively. The difference in rates between the two sexes was not statistically significant（P > 0.05）. Conclusion Modified Baihe Gujin Decoction can significantlyimprove the respiratory and systemic symptoms and signs of pulmonary tuberculosis patients，and it is suitable for both men and women. 

Key words:

pulmonary tuberculosis, anti ?tuberculosis chemotherapy, modified Baihe Gujin decoc? tion, symptoms and signs

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