实用医学杂志 ›› 2022, Vol. 38 ›› Issue (5): 638-643.doi: 10.3969/j.issn.1006⁃5725.2022.05.022

• 综述 • 上一篇    下一篇

内毒素血症影响慢性肝病的研究进展

蒋小铃1 何毅怀1 万典纬1 刘霞1 邱隆敏2   

  1. 遵义医科大学附属医院1 感染科,2 院感科(贵州遵义563000)

  • 出版日期:2022-03-10 发布日期:2022-03-10
  • 通讯作者: 邱隆敏 E⁃mail:Qiulm128@163.com
  • 基金资助:
    国家自然科学资金项目(编号:81560110)

Research progress of effect of endotoxemia on chronic liver disease 

JIANG Xiaoling*,HE Yihuai,WAN Di⁃anwei,LIU Xia,QIU Longmin.    

  1. Department of Infectious Diseases,the Affiliated Hospital of Zunyi Medical Univer⁃sity,Zunyi 563000,China



  • Online:2022-03-10 Published:2022-03-10
  • Contact: QIU Longmin E⁃mail:Qiulm128@163.com

摘要:

慢性肝脏疾病是全球重要的健康负担,每年死于慢性肝脏疾病的人数占全球所有死亡人数的 3.5%。血清内毒素水平与肝病密切相关,它可通过直接或间接作用引起或加重肝损伤,但内毒素血症在肝损伤中的具体作用目前仍不明确,结合最新肠⁃肝轴相关研究发现,内毒素在肝损伤进展中的作用还可能被严重低估,本文重点综述内毒素血症在慢性肝脏疾病的发生、发展过程中的作用及机制,为临床指导慢性肝脏疾病的治疗提供理论基础 。

关键词: 内毒素血症, 脂多糖, 慢性肝脏疾病, 肠道屏障, 肠?肝轴

Abstract:

Chronic liver disease is a significant global health burden,accounting for 3.5% of all deathsworldwide each year. Serum endotoxin level is closely related to end ⁃stage liver disease ,which can cause oraggravate liver injury in direct or indirect way. However,the specific role of endotoxemia in liver injury is not yetclear. The latest gut⁃liver axis related studies found that the role of endotoxin in the progression of liver injurymay be seriously underestimated. Therefore,this article focuses on the mechanism and role of endotoxemia in theoccurrence and development of chronic liver disease,thus to provide theoretical basis for clinical guidance for thetreatment of chronic liver disease.

Key words:

axis