实用医学杂志 ›› 2021, Vol. 37 ›› Issue (23): 3026-3030.doi: 10.3969/j.issn.1006⁃5725.2021.23.013

• 临床研究 • 上一篇    下一篇

右美托咪定联合腹横肌平面阻滞对腹腔镜结直肠手术患者术后胃肠道功能的影响

刘超磊1 苑雪娇2 孙章楠1 邸立超1 康荣田1 黄立宁1 王士朝1 李进1 蒋素芳1 孟明俊1   

  1. 河北医科大学第二医院1 麻醉科,2 全科医疗科(石家庄 050000)

  • 出版日期:2021-12-10 发布日期:2021-12-10
  • 通讯作者: 康荣田 E⁃mail:kangrongtian@126.com ​
  • 基金资助:
    河北医科大学第二医院课题(编号:2h2019050);2020 年河北省政府资助省级医学优秀人才项目

Effect of dexmedetomidine combined with transverse abdominal plane block on gastrointestinal function in patients undergoing laparoscopic colorectal surgery

LIU Chaolei*,YUAN Xuejiao,SUN Zhangnan,DI Li⁃ chao,KANG Rongtian,HUANG Lining,WANG Shizhao,LI Jin,JIANG Sufang,MENG Mingjun.   

  1. Department of Anesthesiathe Second Hospital of Hebei Medical UniversityShijiazhuang 050000China 

  • Online:2021-12-10 Published:2021-12-10
  • Contact: KANG Rongtian E⁃mail:kangrongtian@126.com
  • Supported by:


摘要:

目的 探讨右美托咪定联合腹横肌平面阻滞(TAPB)对腹腔镜结直肠手术患者术后胃肠道 功能的影响。方法 选取择期行腹腔镜结直肠手术的患者 82 例,随机分为右美托咪定+TAPB(研究组)和 生理盐水(对照组),每组 41 例。观察两组术后不同时间点 I⁃FEED 评分、术后胃肠道功能障碍(POGD)发 生情况、炎性因子水平及康复指标。结果 (1)研究组患者术后 24、48、72  96 h  I⁃FEED 评分均低于对 照组(< 0.05);(2)研究组患者 POGD 发生率、术后恶心呕吐发生率分别为 7.32%、19.51%,对照组患者 POGD 发生率、术后恶心呕吐分别为34.15%、48.78%,组间比较差异有统计学意义(< 0.05);(3)研究组患 者术中瑞芬太尼泵注用量,术后 24、48、72 h  VAS 评分和术后镇痛泵按压次数均小于对照组(< 0.05); 4)研究组患者首次排便时间、首次经口进食时间及首次下床活动时间均明显短于对照组(< 0.05);(5 两组治疗后 1 d 研究组患者 CRP、TNF⁃α 及治疗后 3 d IL⁃1β 水平明显低于对照组(< 0.05)。结论 腹腔 镜结直肠手术患者采取右美托咪定联合 TAPB,可加快患者康复进程,为腹腔镜结直肠手术患者 POGD  治提供有效策略。

关键词:

腹腔镜手术,  , 术后胃肠功能障碍,  , 右美托咪定,  , 腹横肌平面阻滞

Abstract:

Objective To investigate the effect of dexemetomidine combined with transverse abdominal plane block(TAPB)on postoperative gastrointestinal function in patients with laparoscopic colorectal surgery. Methods Eighty⁃two patients with selected laparoscopic colorectal surgery were randomly divided into DM + TAPB (study group)and saline(control group)in equal number. I⁃FEED scores at different postoperative time points postoperative gastrointestinal dysfunction(POGD)occurrence,inflammatory factor level and recovery indicators were observed and compared between the two groups. Results (1)The I⁃FEED scores of the study group were lower than those of the control group at 24,48,72 and 96 h,respectively(P < 0.05).(2)The incidences of POGD and PONV in the study group significantly lower than those of the control group,respectively(7.32% vs. 34.15%;19.51% vs. 48.78%,P < 0.05).(3)The dose of intraoperative refentanyl by pump injection in the study group,the VAS scores and the number of postoperative analgesic compressions at 24,48 and 72 h were significantly smaller than in the control group(P < 0.05).(4)The time of first defecation time,first oral feeding and first off⁃bed activity of the study group was significantly shorter than that of the control group(P < 0.05).(5)The levels of CRP,TNF⁃α in 1 d I and 3 d IL⁃1β after treatment were significantly lower after treatment than in the control group(P < 0.05). Conclusion Dex⁃ emetomidine combined with TAPB can effectively prevent the occurrence of POGD in patients having undergone laparoscopic colorectal surgery,accelerate their recovery,and provide effective strategies for POGD treatment.

Key words:

laparoscopic surgery, postoperative gastrointestinal dysfunction, dexmedetomidine, transverse abdominal plane block