实用医学杂志 ›› 2021, Vol. 37 ›› Issue (19): 2535-2539.doi: 10.3969/j.issn.1006⁃5725.2021.19.020

• 医学检查与临床诊断 • 上一篇    下一篇

超声极速成像技术在痛风性关节炎患者颈动脉弹性功能检测中的应用

张思婷 蔡焱 李碧 孙志丹   

  1. 锦州医科大学附属第一医院超声科（辽宁锦州 121001）


  • 出版日期:2021-10-10 发布日期:2021-10-10
  • 通讯作者: 孙志丹 E⁃mail：szdpost@126.com
  • 基金资助:
    辽宁省自然科学基金计划重点项目（编号：20180530009）

Detection of carotid artery elastic function with ultrafast ultrasound imaging technology in patients with gouty arthritis

ZHANG Siting，CAI Yan，LI Bi，SUN Zhidan.   

  1. Department of Ultrasound，the First Affiliated Hospital of Jinzhou Medical University，Jinzhou 121001，China

  • Online:2021-10-10 Published:2021-10-10
  • Contact: SUN Zhidan E⁃mail：szdpost@126.com

摘要：

目的 探讨应用超声极速成像技术（UFUI）在测量痛风性关节炎（gouty arthritis，GA）患者颈 动脉弹性中的临床应用价值。方法 选取痛风性关节炎患者为 GA 组（102 例），并根据是否合并骨质侵蚀 情况，将 GA 组分为非骨质侵蚀组（52 例）及骨质侵蚀组（50 例）。另将同时期来我院体检的 54 例健康志愿 者纳入对照组。比较全体受试者的血压、血脂、尿酸、颈动脉内-中膜厚度（IMT）、收缩期起始时脉搏波传 导速度（BS）及收缩期结束时脉搏波传导速度（ES）等指标。结果 （1）GA 组尿酸、IMT、BS、ES 较对照组明 显增高（P < 0.05），GA 组年龄、体质指数、收缩压、舒张压、总胆固醇、甘油三酯及高密度脂蛋白胆固醇较 对照组比较差异无统计学意义（P > 0.05）。（2）GA 组中，骨质侵蚀组 BS、ES、病程明显高于非骨质侵蚀组 （P < 0.05），两亚组间 IMT、年龄、体质指数、血压、血脂、尿酸比较差异无统计学意义（P > 0.05）。（3）GA 组 患者 BS、ES 分别与 IMT 呈正相关。对照组、非骨质侵蚀组、骨质侵蚀组BS 分别为（5.12 ± 0.76）m/s、（5.90 ± 0.84）m/s、（6.81 ± 0.76）m/s，ES 分别为（6.93 ± 0.96）m/s、（8.60 ± 1.19）m/s、（9.50 ± 0.79）m/s。结论 痛风性关节炎患者 BS 及 ES 增高，颈动脉硬度增高、弹性下降。UFUI 技术可以早期发现痛风性关节炎患者颈动 脉弹性功能变化，为临床早期评估颈动脉粥样硬化提供重要参考依据。

关键词:

极速脉搏波, 痛风性关节炎, 脉搏波传导速度, 颈动脉弹性, 动脉粥样硬化

Abstract:

Objective To explore the clinical value of ultrafast ultrasound imaging（UFUI）in measuring carotid artery elasticity in patients with gouty arthritis（GA）. Methods Totally 102 GA patients were selected， and according to whether combined with bone erosion，they were divided into non⁃bone erosion GA group（n = 52） and bone erosion GA group（n = 50）. In addition，54 healthy volunteers in our hospital for physical examination during the same period were included in the control group. Blood pressure，blood lipids，uric acid，carotid artery⁃ media thickness（IMT），pulse wave velocity at the beginning of the systole（BS），and at the ending of the systole （ES）in all the participants were compared. Results （1）Uric acid，IMT，BS and ES in the GA group were signif⁃ icantly higher than those in the control group（P < 0.05）. There was no difference in age，body mass index，systol⁃ ic blood pressure，diastolic blood pressure，total cholesterol，triglycerides and high⁃density lipoprotein cholesterol in the GA group when compared with the control group（P > 0.05）.（2）In the GA group，the BS，ES and the course of the disease of the bone erosion group were significantly higher than those of the non⁃bone erosion group（P < 0.05）. There was no difference in IMT，age，body mass index，blood pressure，blood lipids and uric acid between the two subgroups（P > 0.05）.（3）BS and ES of GA group were positively correlated with IMT. The pulse wave velocity at the beginning of the systole of the control group，the non⁃bone erosion GA group and the bone erosion GA group were（5.12 ± 0.76）m/s，（5.90 ± 0.84）m/s and（6.81 ± 0.76）m/s，respectively. The pulse wave velocity at the ending of the systole of the control group，the non ⁃bone erosion GA group and the bone erosion GA group were（6.93 ± 0.96）m/s，（8.60 ± 1.19）m/s and（9.50 ± 0.79）m/s，respectively. Conclusion BS and ES are increased in GA patients；carotid artery stiffness is increased and the elasticity is down. UFUI technology can detect the changes of carotid artery elastic function in GA patients in the early time，which provides important referencefor early clinical evaluation of carotid atherosclerosis.

Key words:

ultrafast ultrasound imaging, gouty arthritis, pulse wave velocity, carotid artery elastici? ty, atherosclerosis

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