实用医学杂志 ›› 2026, Vol. 42 ›› Issue (4): 611-617.doi: 10.3969/j.issn.1006-5725.2026.04.010

• 临床诊疗新技术与应用 • 上一篇    

术中按需喷洒二甲硅油联合硫酸镁钠钾溶液在结肠镜肠道准备中的应用效果

郑永娉1,彭程1,任喜梅1,公茂峰2,刘阳1,3()   

  1. 1.南京医科大学附属江宁医院消化内科 （江苏 南京 211100 ）
    2.南京市第一医院介入血管科 （江苏 南京 210000 ）
    3.南京医科大学康达学院江宁临床医学院 （江苏 南京 211100 ）
  • 收稿日期:2025-11-07 出版日期:2026-02-25 发布日期:2026-02-25
  • 通讯作者: 刘阳 E-mail:641499904@qq.com
  • 基金资助:
    国家自然科学基金项目(82200582);江苏省医学会专项基金项目（编号(SYH-3201140-0088);江苏省医学会专项基金项目（编号(2023035);南京医科大学康达学院科研发展基金项目(KD2024KYJJ258)

Evaluation of the application value of intraoperative spraying dimethicone as needed combined with oral sulphate solution in colonoscopy

Yongping ZHENG1,Cheng PENG1,Ximei REN1,Maofeng GONG2,Yang LIU1,3()   

  1. 1.Department of Gastroenterology，the Affiliated Jiangning Hospital of Nanjing Medical University，Nanjing 211100，Jiangsu，China
    2.Department of Interventional Angiology，Nanjing First Hospital，Nanjing 210000，Jiangsu，China
    3.Jiangning Clinical Medical College，Kangda College of Nanjing Medical University，Nanjing 211100，Jiangsu，China
  • Received:2025-11-07 Online:2026-02-25 Published:2026-02-25
  • Contact: Yang LIU E-mail:641499904@qq.com

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摘要：

目的 评价术中按需喷洒二甲硅油联合硫酸镁钠钾口服用浓溶液（OSS）在结肠镜检查肠道准备中的效果，并与术前常规口服二甲硅油方案进行比较。 方法 纳入360例2025年1—8月于南京医科大学附属江宁医院行结肠镜检查的患者，按随机数字表法分为对照组（OSS联合术前常规口服二甲硅油）及观察组（OSS联合术中按需喷洒二甲硅油），每组各180例，分别对比两组的肠道清洁程度、气泡残留情况、检查耗时、息肉检出率及不良反应。 结果 对比发现，两组方案在肠道清洁度方面，各段肠道BBPS得分及总分对比差异无统计学意义（2.42 ± 0.59 vs. 2.48 ± 0.54、2.62 ± 0.49 vs. 2.64 ± 0.48、2.73 ± 0.46 vs. 2.71 ± 0.47、7.78 ± 1.16 vs. 7.83 ± 1.14，均P > 0.05）；气泡评分方面，观察组各段肠道气泡评分及总分均优于对照组（2.77 ± 0.42 vs. 2.27 ± 0.59、2.87 ± 0.34 vs. 2.37 ± 0.52、2.92 ± 0.27 vs. 2.70 ± 0.50、8.56 ± 0.74 vs. 7.34 ± 0.99，均P < 0.01），差异有统计学意义；气泡分级方面，观察组各段肠道评为A级占比显著高于对照组（76.67% vs. 34.44%、86.67% vs. 38.89%、92.22% vs. 70.00%，均P < 0.01），差异有统计学意义；检查耗时方面，观察组检查耗时略高于对照组（12.43 ± 2.52 vs. 11.40 ± 2.33，P > 0.05），差异无统计学意义；观察组微小息肉检出率高于对照组（21.6% vs. 12.7%，P < 0.05），差异有统计学意义；两组患者均耐受较好，不良反应轻微。 结论 术中按需喷洒二甲硅油联合OSS祛泡效果更佳，进一步提升了肠道准备质量，且能提高微小息肉检出率，为进一步优化肠道准备方案提供了参考，具有重要的临床应用价值。

关键词: 结直肠癌, 肠道准备, 气泡评分, 二甲硅油, 硫酸镁钠钾口服用浓溶液

Abstract:

Objective To evaluate the efficacy of intraoperative spraying of dimethicone as needed， combined with oral sulphate solution （OSS）， for bowel preparation， and compare this efficacy with that of conventional oral dimethicone before colonoscopy. Methods A total of 360 patients who underwent colonoscopy at the Affiliated Jiangning Hospital of Nanjing Medical University from January to August 2025 were selected. According to the random number table method， they were divided into two groups： the control group （receiving OSS combined with oral dimethicone before colonoscopy） and the observation group （receiving OSS combined with intraoperative spraying of dimethicone as needed）. The differences in intestinal cleanliness， bubble score， examination duration， polyp detection rate， and adverse reactions between the two groups were compared. Results Comparative analysis revealed no statistically significant difference in the intestinal cleanliness of the BBPS score between the two groups （2.42 ± 0.59 vs. 2.48 ± 0.54， 2.62 ± 0.49 vs. 2.64 ± 0.48， 2.73 ± 0.46 vs. 2.71 ± 0.47， 7.78 ± 1.16 vs. 7.83 ± 1.14， P > 0.05）. The bubble score of the observation group demonstrated superior results in all intestinal segments （2.77 ± 0.42 vs. 2.27 ± 0.59， 2.87 ± 0.34 vs. 2.37 ± 0.52， 2.92 ± 0.27 vs. 2.70 ± 0.50， 8.56 ± 0.74 vs. 7.34 ± 0.99， P < 0.01）. In terms of bubble grading， the observation group showed significantly higher proportions of Grade A ratings in all intestinal segments compared to the control group （76.67% vs. 34.44%， 86.67% vs. 38.89%， 92.22% vs. 70.00%， P < 0.01）. Regarding the examination duration， the observation group took slightly longer than the control group with no statistically significant difference （12.43 ± 2.52 vs. 11.40 ± 2.33， P > 0.05）. The detection rate of micro-polyps in the observation group was higher than that in the control group （21.6% vs. 12.7%， P < 0.05）. Additionally， patients in the two groups demonstrated good tolerance with mild adverse reactions. Conclusions The application of intraoperative spraying of dimethicone as needed， combined with OSS， achieved a better defoaming effect. This can further improve the quality of intestinal preparation and the detection rate of micro-polyps， providing a reference for optimizing the intestinal preparation scheme and having significant clinical application value.

Key words: colorectal cancer, bowel preparation, bubble score, dimethicone, oral sulphate solution

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