实用医学杂志 ›› 2023, Vol. 39 ›› Issue (19): 2551-2555.doi: 10.3969/j.issn.1006-5725.2023.19.024

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SphK1/S1P在肿瘤恶性生物学行为中的研究进展

张文路1,徐春燕2()   

  1. 1.滨州医学院附属医院,呼吸与危重症医学科,消化病研究所 (山东 滨州 256603 )
    2.滨州医学院附属医院,消化内科,消化病研究所 (山东 滨州 256603 )
  • 收稿日期:2023-06-15 出版日期:2023-10-10 发布日期:2023-11-22
  • 通讯作者: 徐春燕 E-mail:xxswallow@163.com
  • 基金资助:
    山东省医药卫生科技发展计划项目(2019WS331)

Progress of SphK1/S1P in the biological behavior of tumor malignancy

Wenlu ZHANG1,Chunyan. XU2()   

  1. *.Department of Respiratory and Critical Care Medicine,Binzhou Medical University Hospital,Binzhou 256603,China
  • Received:2023-06-15 Online:2023-10-10 Published:2023-11-22
  • Contact: Chunyan. XU E-mail:xxswallow@163.com

摘要:

鞘磷酸激酶1(sphingosin kinase 1,SphK1)是一种鞘磷脂代谢产物的调节因子,催化鞘氨醇转变为鞘氨醇-1-磷酸(sphingosine 1 phosphate acid,S1P)。SphK1/S1P在多种癌症中过表达,本文回顾SphK1/S1P在肿瘤恶性生物学行为如肿瘤细胞增殖、上皮间质转化、获得干细胞样特性、重塑肿瘤微环境、调节肿瘤免疫功能、促进肿瘤细胞远处转移中的作用及机制,表明SphK1/S1P在肿瘤多个恶性生物学行为中起关键作用。

关键词: 鞘磷酸激酶1, 鞘氨醇-1-磷酸, 肿瘤恶性生物学行为

Abstract:

Sphingophosphokinase 1 (SphK1) is a regulator of sphingomolipin metabolites that catalyzes the conversion of sphingosine-1-phosphate (S1P) to sphingosine-1-phosphate. SphK1/S1P is overexpressed in a variety of cancers. This paper reviewed the role and mechanism of SphK1/S1P in malignant biological behaviors of tumors, such as tumor cell proliferation, epithelial mesenchymal transformation, acquisition of stem-like properties, remodeling of tumor microenvironment, regulation of tumor immune function, and promotion of distant metastasis of tumor cells. It is suggested that SphK1/S1P plays a key role in multiple malignant biological behaviors of tumors.

Key words: sphingosin kinase 1, sphingosine-1-phosphate, malignant biological behavior of tumor

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