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膝关节骨性关节炎, 骨质疏松, 五聚素3, C1q/TNF 相关蛋白

Abstract:

Objective To study the relationship between the expression of serum pentamerin 3（PTX3） and C1q/TNF related protein 3（CTRP3）and the severity of osteoporosis（OP）in patients with knee osteoarthritis （KOA）complicated with OP. Methods 154 cases of KOA diagnosed and treated in our hospital from January 1st，2018 to December 1st，2021 were selected as the research object，including patients with KOA and OP as the KOA + OP group（92 cases），patients with simple KOA as the KOA group（62 cases），and 40 healthy people in the same period as the control group. The levels of serum PTX3 and CTRP3 were determined using enzyme⁃linked immunosorbent assay. The levels of serum PTX3 and CTRP3 in each group were compared. The levels of serum PTX3 and CTRP 3 and the severity of KOA disease，as well as the relationship between them and serum bone metabolism were statistically analyzed. Results The expression of serum PTX3 and bone metabolism indexes CT， BGP and OPG in KOA + OP group were significantly higher than the control group and KOA group，and CTRP3 was significantly lower than the control group and KOA group（P < 0.05）. Serum PTX3 and CTRP3 levels differed significantly between patients with different KOA severity grades and OP groups（P < 0.05）. The areas under the curve of serum PTX3，CTRP3 and combined detection for predicting KOA with OP were 0.673（95%CI：0.611 ~ 0.735），0.713（95%CI：0.633 ~ 0.762）and 0.824（95%CI：0.780 ~ 0.867），respectively. The area under the curve of PTX3 and CTRP3 combined detection for the diagnosis of KOA with OP had a significantly larger than that of PTX3 and CTRP3 alone（Z = 3.588，3.265，P = 0.000，0.003）. Conclusion In patients with KOA and OP， serum PTX3 expression is increased while CTRP3 expression is decreased. Both are related to the severity of KOA and the degree of osteoporosis. The combined detection aids in the diagnosis of KOA in conjunction with OP.

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