关键词:

胃癌, 抑瘤素M, 细胞分化抑制因子?1

Abstract:

Objective To investigate the expression of oncostatin M（OSM），inhibitor of cell Differentia⁃ tion⁃1（Id⁃1）and Foxp3 in gastric cancer tissues and their correlation with pathological feature. Methods Seventy⁃ two patients with gastric cancer who underwent surgical treatment in our hospital from June 2019 to June 2020 were selected. The resected cancer tissues and adjacent tissues of all patients were taken for immunohistochemical stain⁃ ing，and the relative expression levels of inhibin M，Id⁃1 and Foxp3 were detected by Western blot. The correlation between the expression of inhibin M，Id⁃1 and Foxp3 in the cancer tissues of gastric cancer patients was analyzed.Results Compared with that in the adjacent tissues，the relative expression of tumor suppressor M and Id⁃1 was higher，but that of Foxp3 was lower in gastric cancer tissues（P < 0.05）. Compared with patients without lymph node metastasis，patients with gastric cancer with lymph node metastasis had higher relative expression of inhibin M and Id⁃1 but lower relative expression of Foxp3（P < 0.05）. Compared with patients with intraserous invasion， patients with extraserous invasion of gastric cancer had higher relative expression of inhibin M and Id⁃ 1 but lower relative expression of Foxp3（P < 0.05）. Compared with patients with stage Ⅰ and Ⅱ，patients with stage Ⅲ and Ⅳ gastric cancer had lower relative expression of Foxp3（P < 0.05）. The relative expression of inhibin M and Id⁃1 was higher and the relative expression of Foxp3 was lower（P < 0.05）in patients with moderately differentiated gastric cancer when compared with patients with moderately differentiated gastric cancer. The relative expression of gastric cancer when compared with patients with moderately differentiated gastric cancer（P < 0.05）. The expres⁃ sion of inhibin M and Id⁃1 was positivelycorrelated（r = 0.310，P = 0.008）；but the expression of inhibin M and Foxp3（r = -0.422，P = 0.001）and that of Id⁃1 and Foxp3 was negatively correlated（r = -0.308，P = 0.009）.Conclusion The expression of inhibin M，Id⁃1 and Foxp3 is abnormal in gastric cancer，and the relative expres⁃ sion changes of inhibin M，Id⁃1 and Foxp3 are correlated with lymph node metastasis，invasion degree，TNM stage and differentiation degree in gastric cancer patients，and the expression of M，Id⁃1 and Foxp3 is correlated to some extent，which jointly participate in the development and evolution of gastric cancer. 

Key words:

gastric cancer, oncostatin M, inhibitor of cell differentiation?1, lymph node metastasis, degree of infiltration