产后葡萄糖耐量试验监测及行为干预对妊娠期糖尿病产妇患2型糖尿病的预防效果

doi:10.3969/j.issn.1006-5725.2019.16.022

实用医学杂志 ›› 2019, Vol. 35 ›› Issue (16): 2615-2618.doi: 10.3969/j.issn.1006-5725.2019.16.022

产后葡萄糖耐量试验监测及行为干预对妊娠期糖尿病产妇患2型糖尿病的预防效果

陈钰仪, 邓美莲, 邓燕红

广州医科大学附属第三医院妇产科门诊（广州 510150）

收稿日期:2019-05-09 出版日期:2019-08-27 发布日期:2019-08-27
基金资助:
广州市卫生和计划生育科技一般引导项目（编号：20161A010085）

Effects of postpartum OGTT monitoring and intervention on prevention of GDM in pregnant women with T2DM

CHEN Yuyi, DENG Meilian, DENG Yanhong

Outpatient Department of Obstetrics and Gynecology, Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, China

Received:2019-05-09 Online:2019-08-27 Published:2019-08-27

摘要/Abstract

摘要： 目的探讨产后75 g葡萄糖耐量试验（oral glucose tolerance test ,OGTT）监测及行为干预对妊娠期糖尿病（gestational diabetes mellitus,GDM）产妇患2型糖尿病（type 2 diabetes mellitus,T2DM）的预防效果。方法选取2017年1月至2018年1月在我院就诊的GDM产妇110例,采用随机数字表法,将患者随机分为观察组（n = 56）和对照组（n = 54）,观察组给予产后OGTT监测以及行为干预,对照组仅常规随访,观察两组产后1年T2DM等发生情况。结果观察组产后1年T2DM、糖耐量减低（IGT）/空腹血糖受损（IFG）比例分别为12.50%和21.43%,明显低于对照组（P < 0.05）;干预后1年,观察组2 h OGTT血糖值为（9.01 ± 1.81）mmol/L,明显低于产前以及对照组（P < 0.05）;干预后1年,观察组甘油三酯（TG）为（0.98 ± 0.13）mmol/L,明显低于对照组（P < 0.05）,观察组和对照组总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）和低密度脂蛋白胆固醇（LDL-C）比较差异无统计学意义（P > 0.05）。结论产后OGTT监测及行为干预可有效预防GDM产妇患T2DM的发生,值得临床使用。

关键词: 葡萄糖耐量试验, 妊娠期糖尿病, 2型糖尿病, 产后

Abstract: Objective To investigate the effects of postnatal 75g oral glucose tolerance test（OGTT） monitoring and intervention on the prevention of type 2 diabetes mellitus （T2DM） in pregnant women with gestational diabetes mellitus （GDM）. Methods From January 2017 to January 2018, 110 cases of pregnant women withGDM were recruited in our hospital.The patients were randomly divided into intervention group （n = 56） and control group （n = 54） by random digital table method. The intervention group was given postnatal OGTT monitoring and behavioral intervention, whereas the control group was only followed up routinely. The occurrence of T2DM in the two groups after 1 years was observed. Results In the experimental group, the postpartum ratio of T2DM, impaired glucose tolerance （IGT） /impairedfasting blood glucose （IFG） were 12.50% and 21.43% 1 years after intervention, which was significantly lower than that in the control group （P < 0.05）.One years after intervention, the 2h OGTT blood glucose level of the intervention group was （9.01 ± 1.81） mmol/L, which was significantly lower than that of the control group （P < 0.05）. One year after intervention, thetriglyceride（TG） in the intervention group was （0.98 ± 0.13） mmol/L, which was significantly lower than that in the control group （P < 0.05）. There were no significant difference in total cholesterol （TC）, high density lipoprotein cholesterol （HDL-C） and low density lipoprotein cholesterol （LDL-C） in the intervention group and the control group （P > 0.05）. Conclusion Postpartum OGTT monitoring and intervention can effectively prevent the occurrence of T2DM in GDM pregnant women, which is worthy of clinical application.

Key words: oral glucose tolerance test, gestational diabetes mellitus, type 2 diabetes mellitus, postpartum

陈钰仪, 邓美莲, 邓燕红. 产后葡萄糖耐量试验监测及行为干预对妊娠期糖尿病产妇患2型糖尿病的预防效果[J]. 实用医学杂志, 2019, 35(16): 2615-2618.

CHEN Yuyi, DENG Meilian, DENG Yanhong. Effects of postpartum OGTT monitoring and intervention on prevention of GDM in pregnant women with T2DM[J]. The Journal of Practical Medicine, 2019, 35(16): 2615-2618.

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产后葡萄糖耐量试验监测及行为干预对妊娠期糖尿病产妇患2型糖尿病的预防效果

Effects of postpartum OGTT monitoring and intervention on prevention of GDM in pregnant women with T2DM

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