Abstract:

 With the use of broad ⁃spectrum antibiotics，the resistance of bacteria and fungi to antibiotics continues to increase，and the clinically available drugs are becoming more limited. Biofilm is an important means for drug ⁃ resistant bacteria to adapt to the environment and produce drug resistance. In recent years，continuous studies have shown that traditional Chinese medicine（TCM）extracts can be used alone or in combination with anti⁃ biotics to play a good anti⁃biofilm effect in biofilm⁃related infections. It suggested that TCM is likely to be an auxil⁃ iary or even an alternative drug for resistant bacterial infections. And in vivo research is a link of TCM to clinical practice. In this review，we will review the mechanism of biofilm resistance and the inhibitory effects of various TCM extracts on biofilms of different drug⁃resistant bacteria in vivo experiments，in order to provide reference for the application of TCM in clinical biofilm⁃related drug resistant bacteria infection。

Key words:

Chinese medicine, biofilm, in vivo