Abstract:

Objective To investigate the correlation between the efficacy of computer ⁃assisted cognitive training（CCT）for mild cognitive impairment and Lp ⁃ PLA2 and ApoEε4 genes，and discuss the mechanism of their related action. Methods Among the patients confirmed as mild cognitive impairment，55 cases were randomly assigned to the experimental group and 35 cases to the control group. The interventions were CCT for 3 months，3 times per week，20 minutes each time. The neuropsychological scale was used to evaluate the serum Lp⁃PLA2 level and apoEε4 before and after the treatment，and to evaluate the correlation between them. Results The level of cognitive assessment in the experimental group was significantly higher than that in the control group（P＜0.05）. The level of cognitive changes in the experimental group was similar to that of Lp⁃PLA2（P＜0.05）showed signifi⁃ cant negative correlation. The cognitive change level of ApoEε4 carriers was significantly higher than that of non⁃ carriers（P＜0.05）. Whether ApoEε4 is carried or not，the level of Lp⁃PLA2 has statistical difference（P＜0.05）. Conclusion CCT is effective for patients with mild cognitive impairment，and the results are influenced by APOEε4 gene and the level of Lp ⁃PLA2，which are not completely independent，and may synergistically act on the process of cognitive decline.

Key words:

mild cognitive impairment, computer assisted cognitive training, ApoE gene polymor? phism, lipoprotein associated phospholipase A2