Abstract:

Objective To observe the effect of a comprehensive program based on the theory of multi⁃ sensory stimulation on the sleep function in elderly patients with post ⁃ischemic stroke insomnia（PSI）. Methods A total of 72 PSI patients were selected from our hospital and randomly divided into observation group and control group. The observation group adopted a comprehensive plan based on the multi⁃sensory stimulation theory，that is， a variety of interventions were creatively compressed in a sleeping house within one hour at one location；the con⁃ trol group was treated with conventional western medicine，and both groups were intervened for 4 weeks. Pittsburgh Sleep Quality Index（PSQI），Athens Insomnia Scale（AIS），Anxiety Self⁃Rating Scale（SAS），serum tumor necrosis factor alpha（TNF⁃α），interleukin 6（IL⁃6），serotonin（5⁃HT），sleep chart were used to monitor sleep efficiency，total sleep time，number of night awakening before intervention，4 weeks after intervention，and 3 months after intervention；The sleep efficacy was determined 3 months after the intervention. Results In terms of PSQI score，the two groups after 4 weeks of intervention were lower than those before the intervention，and there was no significant difference between the two groups（P > 0.05）；3 months after the intervention，the observation group was lower than the control group（P < 0.05）. In terms of AIS scores，the two groups were lower than before the intervention for 4 weeks，and the control group was lower than the observation group（P < 0.05）；the observation group was higher than the control group 3 months after the intervention，the difference was statistically significant Meaning（P < 0.05）. In terms of SAS scores，the two groups were lower than before the intervention for 4 weeks， and the observation group was lower than the control group（P < 0.05）；the observation group was lower than the control group 3 months after the intervention，the difference was statistically significant Meaning（P < 0.05）. In terms of TNF⁃α and IL⁃6，the two indicators of the two groups were lower than before the intervention for 4 weeks and 3 months after the intervention. The comparison between the two groups was lower than the control group at both time points，and the difference was statistically significant（P < 0.05）. In terms of 5⁃HT，the two groups were higher than before the intervention 4 weeks after the intervention，while the observation group was higher than before the intervention 3 months after the intervention（P < 0.05），while the control group was not different from before the intervention（P > 0.05），the observation group was higher than the control group，the difference was statistically significant（P < 0.05）. In terms of sleep efficiency in sleep patterns，the two time nodes of the two groups were higher than before the intervention for 4 weeks and 3 months after the intervention，and the observation group was higher than the control group in comparison between the groups，and the difference was statistically significant （P < 0.05）. In terms of total sleep time，after 4 weeks of intervention，both groups were higher than before inter⁃ vention，and the comparison between the two groups was higher than the observation group in the control group， the difference was statistically significant（P < 0.05）；only the observation group was higher in the 3 months after intervention Before the intervention，there was no statistical difference in the control group（P > 0.05），and the observation group was higher than the control group in comparison between the groups，and the difference was statistically significant（P < 0.05）. In terms of the number of night awakening，the two time points of the two groups were lower than those before the intervention for 4 weeks and 3 months after the intervention，and the difference was statistically significant（P < 0.05）；and the comparison between the groups was two weeks after the intervention. There was no difference between the two groups，the observation group was lower than the control group 3 months after intervention，and the difference was statistically significant（P < 0.05）. In terms of curative effect，3 months after the intervention，the marked efficiency of the observation group was 83.33% and that of the control group was 30.56%，the difference was statistically significant（P < 0.05）. Conclusion A comprehensive program based on the multi⁃sensory stimulation theory could not only effectively relieve sleep disorders and anxiety symptoms ，but also integrate multiple treatments with high efficiency to fully utilize the treatment time. It is worthy of further clinical study and promotion. 

Key words:

MSs, comprehensive plan, elderly, PSI, sleep function