脓肿分枝杆菌耐药机制、临床药敏检测及治疗研究进展

doi:10.3969/j.issn.1006-5725.2026.07.003

Abstract

Abstract:

The Mycobacterium abscessus complex （MABC） stands as the most prevalent clinically pathogenic rapidly-growing nontuberculous mycobacterium， with a distinct preference for the respiratory tract. Its rapid growth and substantial disparities in drug resistance among subspecies make the treatment of drug-resistant infections arduous. This article conducts a comprehensive review of the molecular mechanisms of drug resistance in MABC. These mechanisms include erm（41）-mediated inducible macrolide resistance， acquired macrolide resistance resulting from rrl gene mutations， and the mechanisms behind aminoglycoside resistance， such as target mutations， inactivation by modifying enzymes， and efflux pumps. It further details the subspecies-specific differences in drug resistance and the characteristics of geographical distribution. Moreover， it summarizes the principles of clinical drug susceptibility testing， highlighting the integrated application of subspecies identification， phenotypic detection， and molecular typing. Integrating the latest research advances， it presents multidrug combination therapy strategies and experimental therapeutic approaches for drug-resistant MABC infections. The aim is to offer references for clinical precision diagnosis and individualized treatment， and to contribute to enhancing the level of diagnosis and treatment of drug-resistant MABC infections.

Key words: Mycobacterium abscessus complex, rapidly growing mycobacteria, nontuberculous mycobacteria, drug resistance, anti-infective therapy

CLC Number:

R378.91

Xiaoyu LAI,Xunxun CHEN,Qinghua LIAO,Meiling YU,Huixin GUO,Jiawen WANG,Yuhui CHEN,Wenpei WEN. Mechanisms of drug resistance， clinical drug susceptibility testing， and advances in treatment of Mycobacterium abscessus[J]. The Journal of Practical Medicine, 2026, 42(7): 1134-1141.

Figures/Tables 1

References 54

[1]	MATSUMOTO Y， KINJO T， MOTOOKA D， et al. Comprehensive subspecies identification of 175 nontuberculous mycobacteria species based on 7547 genomic profiles［J］. Emerg Microbes Infect， 2019， 8（1）： 1043-1053. doi： 10.1080/22221751.2019.1637702 . doi: 10.1080/22221751.2019.1637702
[2]	YANG T， BEACH K E， ZHU C， et al. Genomic Analysis of Global Mycobacterium abscessus Isolates Reveals Ongoing Evolution of Drug Resistance-Associated Genes［J］. J Infect Dis， 2025， 231（5）： 1150-1154. doi： 10.1093/infdis/jiae580 . doi: 10.1093/infdis/jiae580
[3]	HOU Y， PI R， JIA J， et al. Limited predictive power of known resistance genes for phenotypic drug resistance in clinical Mycobacterium abscessus complex from Beijing in China［J］. Antimicrob Agents Chemother， 2025， 69（7）： e0184724. doi： 10.1128/aac.01847-24 . doi: 10.1128/aac.01847-24
[4]	NASH K A， BROWN-ELLIOTT B A， WALLACE R J. A novel gene， erm （41）， confers inducible macrolide resistance to clinical isolates of Mycobacterium abscessus but is absent from Mycobacterium chelonae［J］. Antimicrob Agents Chemother， 2009， 53 （4）： 1367-1376. doi： 10.1128/AAC.01275-08 . doi: 10.1128/AAC.01275-08
[5]	RICHARD M， GUTIÉRREZ A V， KREMER L. Dissecting erm （41）-Mediated Macrolide-Inducible Resistance in Mycobacterium abscessus［J］. Antimicrob Agents Chemother， 2020， 64（2）： e01879. doi： 10.1128/AAC.01879-19 . doi: 10.1128/AAC.01879-19
[6]	CARVALHO N F G， PAVAN F， SATO D N， et al. Genetic correlates of clarithromycin susceptibility among isolates of the Mycobacterium abscessus group and the potential clinical applicability of a PCR-based analysis of erm （41）［J］. J Antimicrob Chemother， 2018， 73（4）： 862-866. doi： 10.1093/jac/dkx476 . doi: 10.1093/jac/dkx476
[7]	WANG X， SU B， CHEN P， et al. Subspecies distribution and drug-resistance characteristics of Mycobacterium abscessus complex clinical isolates in South China［J］. Microbiol Spectr， 2025， 13（5）： e0410323. doi： 10.1128/spectrum.04103-23 . doi: 10.1128/spectrum.04103-23
[8]	YOSHIDA M， CHIEN J Y， MORIMOTO K， et al. Molecular Epidemiological Characteristics of Mycobacterium abscessus Complex Derived from Non-Cystic Fibrosis Patients in Japan and Taiwan［J］. Microbiol Spectr， 2022， 10（3）： e0057122. doi： 10.1128/spectrum.00571-22 . doi: 10.1128/spectrum.00571-22
[9]	BUENESTADO-SERRANO S， MARTÍNEZ-LIROLA M， HERRANZ-MARTÍN M， et al.Microevolution， reinfection and highly complex genomic diversity in patients with sequential isolates of Mycobacterium abscessus［J］. Nat Commun， 2024， 15（1）： 2717. doi： 10.1038/s41467-024-46552-w . doi: 10.1038/s41467-024-46552-w
[10]	SHALLOM S J， ZELAZNY A M. Detection of Mixed Populations of Clarithromycin-Susceptible and Resistant Mycobacterium abscessus Strains［J］. J Clin Microbiol， 2022， 60（4）： e0169421. doi： 10.1128/jcm.01694-21 . doi: 10.1128/jcm.01694-21
[11]	SHARMA M K， LA Y， JANELLA D， et al. A real-time PCR assay for rapid identification of inducible and acquired clarithromycin resistance in Mycobacterium abscessus［J］. BMC Infect Dis， 2020， 20（1）： 944.doi： 10.1186/s12879-020-05686-0 . doi: 10.1186/s12879-020-05686-0
[12]	MWANGI Z， NAEKU G， MUREITHI M， et al.Mutation patterns of resistance genes for macrolides， aminoglycosides， and rifampicin in non-tuberculous mycobacteria isolates from Kenya［J］. F1000 Res， 2023， 11： 962. doi： 10.12688/f1000research.124002.5 . doi: 10.12688/f1000research.124002.5
[13]	LI X， ZHU Y， LU Y， et al. Population genetic analysis of clinical Mycobacterium abscessus complex strains in China［J］. Front Cell Infect Microbiol， 2025， 14： 1496896. doi： 10.3389/fcimb.2024.1496896 . doi: 10.3389/fcimb.2024.1496896
[14]	RUEDAS-LÓPEZ A， TATO M， BRONCANO-LAVADO A， et al. Subspecies Distribution and Antimicrobial Susceptibility Testing of Mycobacterium abscessus Clinical Isolates in Madrid， Spain： A Retrospective Multicenter Study［J］. Microbiol Spectr， 2023， 11（3）： e0504122. doi： 10.1128/spectrum.05041-22 . doi: 10.1128/spectrum.05041-22
[15]	MAURER F P， RÜEGGER V， RITTER C， et al. Acquisition of clarithromycin resistance mutations in the 23S rRNA gene of Mycobacterium abscessus in the presence of inducible erm （41）［J］. J Antimicrob Chemother， 2012， 67（11）： 2606-2611. doi： 10.1093/jac/dks279 . doi: 10.1093/jac/dks279
[16]	YOSHIDA S， TSUYUGUCHI K， KOBAYASHI T， et al.Comparison of drug-susceptibility patterns and gene sequences associated with clarithromycin and azithromycin resistance in Mycobacterium abscessus complex isolates and evaluation of the accumulation of intrinsic macrolide resistance［J］. J Med Microbiol， 2021， 70（3）. doi： 10.1099/jmm.0.001326 . doi: 10.1099/jmm.0.001326
[17]	JONG B E， WU T S， CHEN N Y， et al.Impact on Macrolide Resistance of Genetic Diversity of Mycobacterium abscessus Species［J］. Microbiol Spectr， 2022， 10（6）： e0274922. doi： 10.1128/spectrum.02749-22 . doi: 10.1128/spectrum.02749-22
[18]	LI H， MULATI G， SHANG Y， et al. Rapid Detection of Clarithromycin and Amikacin Resistance in Mycobacterium abscessus Complex by High-Resolution Melting Curve Analysis［J］. Microbiol Spectr， 2022， 10（3）： e0057422. doi： 10.1128/spectrum.00574-22 . doi: 10.1128/spectrum.00574-22
[19]	SUKMONGKOLCHAI S， PETSONG S， OUDOMYING N， et al.Clinical characteristics and drug susceptibility profiles of Mycobacterium abscessus complex infection at a medical school in Thailand［J］. Ann Clin Microbiol Antimicrob， 2023， 22（1）： 87. doi： 10.1186/s12941-023-00637-4 . doi: 10.1186/s12941-023-00637-4
[20]	CHOI H， KIM S Y， KIM D H， et al. Clinical Characteristics and Treatment Outcomes of Patients with Acquired Macrolide-Resistant Mycobacterium abscessus Lung Disease［J］. Antimicrob Agents Ch， 2017， 61（10）： e01146. doi： 10.1128/AAC.01146-17 . doi: 10.1128/AAC.01146-17
[21]	DING J， HAMEED H M A， LONG L， et al.Correlation between rrs gene mutations and amikacin resistance in Mycobacterium abscessus： Implications for fitness cost and clinical prevalence［J］. J Antimicrob Chemother， 2025， 80（3）： 746-751. doi： 10.1093/jac/dkae468 . doi: 10.1093/jac/dkae468
[22]	ZHANG Z， WANG W， WANG Y， et al.Inducible Resistance to Amikacin in Mycobacterium abscessus Isolated in Beijing， China［J］. Infect Drug Resist， 2022， 15： 2287-2291. doi： 10.2147/IDR.S357887 . doi: 10.2147/IDR.S357887
[23]	PRAMMANANAN T， SANDER P， BROWN B A， et al.A single 16S ribosomal RNA substitution is responsible for resistance to amikacin and other 2-deoxystreptamine aminoglycosides in Mycobacterium abscessus and Mycobacterium chelonae［J］. J Infect Dis， 1998， 177（6）： 1573-1581. doi： 10.1086/515328 . doi: 10.1086/515328
[24]	MAURER F P， BRUDERER V L， CASTELBERG C， et al. Aminoglycoside-modifying enzymes determine the innate susceptibility to aminoglycoside antibiotics in rapidly growing mycobacteria［J］. J Antimicrob Chemother， 2015， 70（5）： 1412-1419. doi： 10.1093/jac/dku550 . doi: 10.1093/jac/dku550
[25]	BRYANT J M， GROGONO D M， GREAVES D， et al. Whole-genome sequencing to identify transmission of Mycobacterium abscessus between patients with cystic fibrosis： A retrospective cohort study［J］. Lancet， 2013， 381（9877）： 1551-1560. doi： 10.1016/S0140-6736（13）60632-7 . doi: 10.1016/S0140-6736（13）60632-7
[26]	NESSAR R， CAMBAU E， REYRAT J M， et al. Mycobacterium abscessus： A new antibiotic nightmare［J］. J Antimicrob Chemother， 2012， 67（4）： 810-818. doi： 10.1093/jac/dkr578 . doi: 10.1093/jac/dkr578
[27]	DALEY C L， IACCARINO J M， LANGE C， et al. Treatment of nontuberculous mycobacterial pulmonary disease： An official ATS/ERS/ESCMID/IDSA clinical practice guideline［J］. Eur Respir J， 2020， 56（1）： 2000535. doi： 10.1183/13993003.00535-2020 . doi: 10.1183/13993003.00535-2020
[28]	HAWORTH C S， BANKS J， CAPSTICK T， et al. British Thoracic Society guidelines for the management of non-tuberculous mycobacterial pulmonary disease （NTM-PD）［J］. Thorax， 2017， 72（）： ii1-ii64. doi： 10.1136/thoraxjnl-2017-210927 . doi: 10.1136/thoraxjnl-2017-210927
[29]	BROWN-ELLIOTT B A， VASIREDDY S， VASIREDDY R， et al. Utility of sequencing the erm （41） gene in isolates of Mycobacterium abscessus subsp. abscessus with low and intermediate clarithromycin MICs［J］. J Clin Microbiol， 2015， 53（4）： 1211-1215. doi： 10.1128/JCM.02950-14 . doi: 10.1128/JCM.02950-14
[30]	GRIFFITH D E， Daley C L. Treatment of Mycobacterium abscessus Pulmonary Disease［J］. Chest， 2022， 16（1）： 64-75. doi： 10.1128/JCM.02950-14 . doi: 10.1128/JCM.02950-14
[31]	FLOTO R A， OLIVIER K N， SAIMAN L， et al.US Cystic Fibrosis Foundation and European Cystic Fibrosis Society consensus recommendations for the management of non-tuberculous mycobacteria in individuals with cystic fibrosis： executive summary［J］. Thorax， 2016， 71（1）： 88-90. doi： 10.1136/thoraxjnl-2015-207983 . doi: 10.1136/thoraxjnl-2015-207983
[32]	NEGATU D A， GONZÁLEZ DEL RÍO R， CACHO-IZQUIERDO M， et al. Activity of Oral Tebipenem-Avibactam in a Mouse Model of Mycobacterium abscessus Lung Infection［J］. Antimicrob Agents Chemother， 2023， 67（2）： e0145922. doi： 10.1128/aac.01459-22 . doi: 10.1128/aac.01459-22
[33]	LE MOIGNE V， BITAR M， ARTHUR M， et al. The addition of amoxicillin improves the efficacy of the imipenem-avibactam combination against Mycobacterium abscessus in a mouse model of infection［J］. Antimicrob Agents Chemother， 2025， 69（8）： e0053425. doi： 10.1128/aac.00534-25 . doi: 10.1128/aac.00534-25
[34]	DOUSA K M， KURZ S G， TARACILA M A， et al. Insights into the l，d-Transpeptidases and d，d-Carboxypeptidase of Mycobacterium abscessus： Ceftaroline， Imipenem， and Novel Diazabicyclooctane Inhibitors［J］. Antimicrob Agents Chemother， 2020， 64（8）： e00098. doi： 10.1128/AAC.00098-20 . doi: 10.1128/AAC.00098-20
[35]	LONGO B M， TRUNFIO M， CALCAGNO A. Dual β-lactams for the treatment of Mycobacterium abscessus： A review of the evidence and a call to act against an antibiotic nightmare［J］. J Antimicrob Chemother， 2024， 79（11）： 2731-2741. doi： 10.1093/jac/dkae288 . doi: 10.1093/jac/dkae288
[36]	BEECH A J， WEINBERG S E， MORTIMER A E， et al. Mycobacterium abscessus skin and soft tissue infection following autologous fat grafting in Kurdistan treated with an antibiotic combination including Imipenem-Relebactam and Rifabutin［J］. J Clin Tuberc Other Mycobact Dis， 2023， 32： 100381. doi： 10.1016/j.jctube.2023.100381 . doi: 10.1016/j.jctube.2023.100381
[37]	VOGIATZOGLOU A I， HADJI ΜITROVA M， PAPADAKI E， et al.Combination of Imipenem-Cilastatin-Relebactam and Amoxicillin in the Antibiotic Regimen in Two Cases of Mycobacterium abscessus Lung Infection［J］. Cureus， 2024， 16（7）： e65112. doi： 10.7759/cureus.65112 . doi: 10.7759/cureus.65112
[38]	YAMATANI I， AONO A， FUJIWARA K， et al.In vitro effects of the new oral β-lactamase inhibitor xeruborbactam in combination with oral β-lactams against clinical Mycobacterium abscessus isolates［J］. Microbiol Spectr， 2024， 12（7）： e0008424. doi： 10.1128/spectrum.00084-24 . doi: 10.1128/spectrum.00084-24
[39]	STORY-ROLLER E， GALANIS C， LAMICHHANE G.β-Lactam combinations that exhibit synergy against Mycobacteroides abscessus clinical isolates［J］. Antimicrob Agents Chemother， 2021， 65（10）： e02545-20. doi： 10.1128/AAC.02545-20 . doi: 10.1128/AAC.02545-20
[40]	STORY-ROLLER E， MAGGIONCALDA E C， LAMICHHANE G.Synergistic efficacy of β-lactam combinations against Mycobacterium abscessus pulmonary infection in mice［J］. Antimicrob Agents Chemother， 2019， 63（8）： e00614-19. doi： 10.1128/AAC.00614-19 . doi: 10.1128/AAC.00614-19
[41]	DOUSA K M， KURZ S G， TARACILA M A，et al. Insights into the L，D-transpeptidases and D，D-carboxypeptidase of Mycobacterium abscessus： Ceftaroline， imipenem， and novel diazabicyclooctane inhibitors［J］. Antimicrob Agents Chemother， 2020， 64（8）： e00098-20. doi： 10.1128/AAC.00098-20 . doi: 10.1128/AAC.00098-20
[42]	PEARSON J C， DIONNE B， RICHTERMAN A， et al. Omadacycline for the Treatment of Mycobacterium abscessus Disease： A Case Series［J］. Open Forum Infect Dis， 2020， 7（10）： ofaa415. doi： 10.1093/ofid/ofaa415 . doi: 10.1093/ofid/ofaa415
[43]	FILE T M， RAMIREZ J A， WILDE A M. New Perspectives on Antimicrobial Agents： Omadacycline for community-acquired pneumonia， skin and soft tissue infections， and nontuberculous mycobacteria （focus on M. abscessus）［J］. Antimicrob Agents Chemother， 2025， 69（2）： e0108724. doi： 10.1128/aac.01087-24 . doi: 10.1128/aac.01087-24
[44]	王宇津，荆玮，李强，等. 康替唑胺对脓肿分枝杆菌的抗菌活性研究［J］. 中国医刊， 2024， 59（9）： 1026-1028. doi： 10.3969/j.issn.1008-1070.2024.09.025 . doi: 10.3969/j.issn.1008-1070.2024.09.025
[45]	GAO X， DING C， XIE D， et al. Contezolid-Containing Regimen Successfully Treated Multiple Drug Resistance Mycobacterium Abscessus Complex Infection of Skin： A Case Report and Literature Review［J］. Infect Drug Resist， 2024， 17： 1243-1249. doi： 10.2147/IDR.S453541 . doi: 10.2147/IDR.S453541
[46]	COMPAIN F， SOROKA D， HEYM B， et al. In vitro activity of tedizolid against the Mycobacterium abscessus complex［J］. Diagn Microbiol Infect Dis， 2017， 90（3）： 186-189. doi： 10.1016/j.diagmicrobio.2017.11.001 . doi: 10.1016/j.diagmicrobio.2017.11.001
[47]	BURKE A， CARTER R， TOLSON C， et al.In vitro susceptibility testing of imipenem-relebactam and tedizolid against 102 Mycobacterium abscessus isolates［J］. Int J Antimicrob Agents， 2023， 62（4）： 106938. doi： 10.1016/j.ijantimicag.2023.106938 . doi: 10.1016/j.ijantimicag.2023.106938
[48]	SEKI M， KAMIOKA Y， TAKANO K， et al. Mycobacterium abscessus Associated Peritonitis with CAPD Successfully Treated Using a Linezolid and Tedizolid Containing Regimen Suggested Immunomodulatory Effects［J］. Am J Case Rep， 2020， 21： e924642. doi： 10.12659/AJCR.924642 . doi: 10.12659/AJCR.924642
[49]	KIM T S， CHOE J H， KIM Y J， et al. Activity of LCB01-0371， a Novel Oxazolidinone， against Mycobacterium abscessus［J］. Antimicrob Agents Chemother， 2017， 61（9）： e02752. doi： 10.1128/AAC.02752-16 . doi: 10.1128/AAC.02752-16
[50]	COTRONEO N， STOKES S S， PUCCI M J， et al. Efficacy of SPR720 in murine models of non-tuberculous mycobacterial pulmonary infection［J］. J Antimicrob Chemother， 2024， 79（4）： 875-882. doi： 10.1093/jac/dkae046 . doi: 10.1093/jac/dkae046
[51]	RUBINO C M， ONUFRAK N J， VAN INGEN J， et al. Population Pharmacokinetic Evaluation of Amikacin Liposome Inhalation Suspension in Patients with Treatment-Refractory Nontuberculous Mycobacterial Lung Disease［J］. Eur J Drug Metab Pharmacokinet， 2021， 46（2）： 277-287. doi： 10.1007/s13318-020-00669-7 . doi: 10.1007/s13318-020-00669-7
[52]	PEARCE C Inhaled tigecycline is effective against Mycobacterium abscessus in vitro and in vivo［J］. J Antimicrob Chemoth， 2020， 75（7）： 1889-1894. doi： 10.1093/jac/dkaa110 . doi: 10.1093/jac/dkaa110
[53]	NICK J A， DEDRICK R M， GRAY A L， et al. Host and pathogen response to bacteriophage engineered against Mycobacterium abscessus lung infection［J］. Cell， 2022， 185（11）： 1860-1874. doi： 10.1016/j.cell.2022.04.024 . doi: 10.1016/j.cell.2022.04.024
[54]	DEDRICK R M， GUERRERO-BUSTAMANTE C A， GARLENA R A， et al. Engineered bacteriophages for treatment of a patient with a disseminated drug-resistant Mycobacterium abscessus［J］. Nat Med， 2019， 25（5）： 730-733. doi： 10.1093/ofid/ofac194 . doi: 10.1093/ofid/ofac194

亚种名称	erm（41）功能状态	rrl突变特点	核心耐药表型	主要地理分布	参考文献
脓肿亚种	功能性（可诱导激活）	初始分离株中可见突变，长期大环内酯暴露后突变频率显著上升	诱导性大环内酯耐药，易叠加rrl突变耐药	全球广泛分布，欧美地区检出率> 70%；中国华南地区为优势亚种（52.6%），北京、上海检出率73.8% ~ 75.9%	[9-11,16]
博莱亚种	功能性（可诱导激活）	相关研究数据十分有限，突变特征尚未明确	诱导性大环内酯耐药，氨基糖苷耐药风险高	全球散在分布，临床检出率相对较低	[7,19]
马赛亚种	失活型	初始检出率< 2%，耐药时多为rrl突变	天然大环内酯敏感，罕见诱导性耐药，耐药表型主要由 rrl突变介导	东亚地区为优势亚种之一（日本及中国台湾47.7%、中国华南地区45.4%）；泰国检出率58.1%，为最主要亚种	[7-8,19]

Mechanisms of drug resistance， clinical drug susceptibility testing， and advances in treatment of Mycobacterium abscessus

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