癫痫患者共患抑郁和焦虑危险因素分析及其与生存质量的关系

doi:10.3969/j.issn.1006-5725.2024.04.004

Abstract

Abstract:

Objective To explore the risk factors of depression and anxiety in adult patients with epilepsy and their relationship with quality of life. Methods From May 2022 to January 2023， patients diagnosed with epilepsy （aged ≥ 18 years） in the department of neurology of our hospital were collected. General demographic data and disease?related information were recorded. Quality of life， depression and anxiety scales were measured in all patients. SPSS26.0 software was used for multiple linear regression analysis， multiple ordered Logistic regression analysis， rank sum test， Pearson correlation analysis， etc. Results Among the 111 patients， 49.5% had depression and 43.2% had anxiety. Depression score and anxiety score were correlated with attack type， attack frequency， quality of life and right temporal lobe， and there was a significant negative correlation between life quality score and anxiety and depression score （P < 0.01）. Seizure frequency， seizure type and right temporal lobe were common risk factors for depression and anxiety in patients with epilepsy （P < 0.05）. Conclusion Epileptic depression and anxiety were affected by seizure frequency and seizure type， and this bad mood further affected the quality of life of patients. No clear link has been found between the lateralization of seizures and the presence of depression and anxiety states， and further research is needed.

Key words: comorbidity, neural network, hypothalamic?pituitary?adrenal axis, laterality, epilepsy, depression, anxiety

CLC Number:

R742.1

Wenjie HAN,Youtian ZHOU,Zhensheng LI,Jianjie KANG,Bingmei. DENG. Risk factors of depression and anxiety in epilepsy patients and their relationship with quality of life[J]. The Journal of Practical Medicine, 2024, 40(4): 460-465.

Figures/Tables 6

Tab.1

Tab.2

Fig.1

Tab.3

Tab.5

References 36

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项目		例数	百分比（%）
学历	大学及以上	46	41.4
	高中	19	17.1
	初中及以下	46	41.4
婚姻状况	未婚	55	49.5
	已婚	53	47.7
	离婚	3	2.7
发作类型	全面性发作	24	21.6
	局灶性发作	14	12.6
	局灶继发强直阵挛发作	73	65.8
病变部位用药情况	左侧额叶	11	9.9
	右侧额叶	9	8.1
	左侧颞叶	37	33.3
	右侧颞叶	40	36.0
	右侧顶叶	3	2.7
	右侧顶叶	1	0.9
	右侧岛叶	1	0.9
	右侧岛叶	3	2.7
	左侧枕叶	4	3.6
	右侧枕叶	0	0.0
	奥卡西平	24	21.6
	拉莫三嗪	22	19.8
	丙戊酸钠	28	25.2
	左乙拉西坦	35	31.5
	托吡酯	3	2.7
	拉考沙胺	6	5.4
	吡仑帕奈	2	1.8
	卡马西平	14	12.6

项目		抑郁评分	焦虑评分	项目		抑郁评分	焦虑评分
年龄	皮尔逊相关性	0.190^*	0.229^*	性别	皮尔逊相关性	0.047	0.041
年龄	Sig.（双尾）	0.046	0.015		Sig.（双尾）	0.622	0.666
病程	皮尔逊相关性	0.167	0.162	婚姻状况	皮尔逊相关性	0.131	0.201^*
病程	Sig.（双尾）	0.080	0.089		Sig.（双尾）	0.170	0.034
起病年龄	皮尔逊相关性	0.034	0.074	学历	皮尔逊相关性	0.054	-0.040
起病年龄	Sig.（双尾）	0.725	0.439		Sig.（双尾）	0.572	0.673
左侧额叶	皮尔逊相关性	-0.032	-0.080	奥卡西平	皮尔逊相关性	-0.095	-0.042
	Sig.（双尾）	0.737	0.402		Sig.（双尾）	0.322	0.665
右侧额叶	皮尔逊相关性	-0.100	-0.103	拉莫三嗪	皮尔逊相关性	0.058	0.053
	Sig.（双尾）	0.298	0.281		Sig.（双尾）	0.544	0.580
左侧颞叶	皮尔逊相关性	0.048	-0.022	丙戊酸钠	皮尔逊相关性	0.168	0.177
	Sig.（双尾）	0.619	0.822		Sig.（双尾）	0.078	0.062
左侧顶叶	皮尔逊相关性	0.013	0.009	左乙拉西坦	皮尔逊相关性	-0.074	-0.154
	Sig.（双尾）	0.891	0.925		Sig.（双尾）	0.441	0.106
右侧顶叶	皮尔逊相关性	-0.081	-0.074	托吡酯	皮尔逊相关性	-0.090	0.009
	Sig.（双尾）	0.399	0.440		Sig.（双尾）	0.349	0.925
左侧岛叶	皮尔逊相关性	-0.057	-0.046	拉考沙胺	皮尔逊相关性	0.156	0.164
	Sig.（双尾）	0.555	0.635		Sig.（双尾）	0.101	0.086
右侧岛叶	皮尔逊相关性	-0.020	-0.041	吡仑帕奈	皮尔逊相关性	0.176	0.070
	Sig.（双尾）	0.838	0.670		Sig.（双尾）	0.065	0.463
左侧枕叶	皮尔逊相关性	-0.086	0.009	卡马西平	皮尔逊相关性	0.140	0.186
	Sig.（双尾）	0.367	0.927		Sig.（双尾）	0.144	0.050

系数（a）
	非标准化系数		标准系数
模型	B	标准误差	Beta	t值	P值
（常量）	1.395	3.966		0.352	0.726
发作频率（次/年）	0.228	0.068	0.298	3.333	0.001
右侧颞叶	4.799	2.21	0.194	2.171	0.032
发作类型	2.951	1.475	0.176	2	0.048

系数（b）
	非标准化系数		标准系数
模型	B	标准误差	Beta	t值	P值
（常量）	2.097	3.327		0.63	0.53
发作频率（次/年）	0.129	0.057	0.2	2.252	0.026
右侧颞叶	5.92	1.854	0.283	3.193	0.002
发作类型	3.054	1.237	0.216	2.468	0.015

	右侧颞叶	N	秩均值	秩和	Mann-Whitney U	Wilcoxon W	Z	渐近显著性（双侧）
抑郁评分	否	71	51.04	3 623.5	1 067.5	3 623.5	-2.168	0.03
	是	40	64.81	2 592.5
	总数	111
焦虑评分	否	71	49.02	3 480.5	924.5	3 480.5	-3.047	0.002
	是	40	68.39	2 735.5
	总数	111

Risk factors of depression and anxiety in epilepsy patients and their relationship with quality of life

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