The Journal of Practical Medicine ›› 2023, Vol. 39 ›› Issue (20): 2683-2686.doi: 10.3969/j.issn.1006-5725.2023.20.022

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Research progress of IL⁃18 and IL⁃37b in naïve CD4+ T differentiation of patients with allergic asthma

Junling WANG1,2,Mengmeng ZHAN1,Fangqiu GU2,Zhaolong ZHANG1,Siqin WANG1(),Shaoheng. HE2   

  1. 1.Department of Allergy,Henan Provincial People's Hospital,Zhengzhou University People's Hospital,Zhengzhou 450003,China
    2.Allergy and Clinical Immunology Research Centre, the First Affiliated Hospital of Jinzhou Medical University, Jinzhou 121001, China
  • Received:2023-07-10 Online:2023-10-25 Published:2023-11-15
  • Contact: Siqin WANG E-mail:wangsiqin273@126.com

Abstract:

Allergic asthma (AA) is one of the most common allergic respiratory diseases. CD4+ T cell subtypes play an important role in the pathogenesis of AA. IL-18 and IL-37b are involved in the pathogenesis of AA via binding to IL-18Rα and thus regulating the differentiation of na?ve CD4+ T cells. In view of this, understanding the role of IL-18 and IL-37b in the differentiation of na?ve CD4+ T cells in AA is of great significance for the pathogenesis, diagnosis and treatment of AA, and for the research and development of biological agents.

Key words: allergic asthma, na?ve CD4+ T cell, interleukin-18, interleukin-37b

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