Abstract:

Objective This study aims to investigate the relationship between subchorionic hematoma in the first trimester and lower genital tract infection and embryonic arrest. Methods The method of prospective random⁃ ized trials was used to select 180 women with pregnancy 5 ~ 9 weeks following subchorionic hematoma. and then divide them into the lower genital tract infection group（n = 54）and normal group（n = 126）according to the results of vaginal secretion culture. The relationships of the lower genital tract infections and chorionic hematoma area with the pregnancy outcomes were analyzed. Results There were no significant differences in the average age，gestational days，gestational times and body mass index between the two groups. There was no significant difference in the duration of vaginal bleeding and the duration of lower abdominal pain（P > 0.05）. Etiological analysis showed that the abnormal vaginal flora，the gestational age of subchorionic hematoma < 6 weeks，and the ratio of hematoma to gestational sac area ≥ 50% and between 25% ~ 50% were all the independent risk factors for embryo suspension in early pregnancy. Conclusion Embryo termination in early pregnancy is related to the imbalance between vaginal microbiota and vaginal microbiota，the gestational age of subchorionic hematoma < 6 weeks，and the proportion of hematoma to gestational sac area ≥ 50% and between 25% ~ 50%. In early pregnancy，attention should be paid to the balance of vaginal microflora，timely adjustment of the microecological balance of vaginal microflora，early B⁃ultrasound examination for detecting and treating subchorionic hematoma，in order to obtain a better outcome.

Key words:

subchorionic hematoma, lower genital tract infections, area of subchorionic hematoma, pregnancy outcomes, arrest of embryo development