Abstract:

Objective This study aimed to evaluate the clinical effect of hyaluronic acid（HA） scaffold combined with adipose?derived stem cells（ADSCs） in chronic wound healing of lower limbs and explore its application potential in promoting chronic wound healing. Methods A total of 50 patients were included in this study. They were divided into study and control groups according to the random number table method. There were 25 cases in each of the two groups of patients. HA and ADSCs were mixed in a 1∶1 ratio and evenly injected into the wound base and the subcutaneous tissue around the wound at a rate of 0.1 ml/cm3. In the control group， ADSCs were only injected into the wound base and subcutaneous tissue around the wound. The infection rate， treatment satisfaction， wound healing rate， visual analogue score （VAS）， and wound quantitative score were compared between the two groups at 7 days， 14 days， and 28 days. Results The infection rate in the study group was lower than that in the control group， and the difference was statistically significant （P < 0.05）. Moreover， at 14 days and 28 days after treatment， the wound healing rate in the study group was higher than that in the control group， and the difference was statistically significant （P < 0.05）. On the 7th， 14th， and 28th days after treatment， the VAS scores and the wound quantitative scores were lower than those in the control group， and the difference was statistically significant （P < 0.05）. Furthermore， the treatment satisfaction rate in the research group （92%） was higher than that in the control group （80%）. Conclusion HA scaffold combined with ADSCs could promote the healing of chronic wounds in lower limbs， reduce infection rate， and relieve wound pain， which provides a new idea for the treatment of chronic wounds.

Key words: hyaluronic acid, adipose stem cells, wound healing, infection rate, visual analogue score