线粒体稳态在血管性认知障碍中的研究进展

doi:10.3969/j.issn.1006-5725.2025.12.024

Abstract

Abstract:

Vascular cognitive impairment （VCI） is a type of cognitive dysfunction caused by cerebrovascular lesions， and its pathological mechanism includes mitochondrial damage. Therefore， maintaining mitochondrial homeostasis is crucial in the occurrence and progression of VCI. Mitochondrial homeostasis involves multiple levels， including biogenesis， autophagy， ion balance， protein quality control， membrane dynamics， and interactions with other organelles. This study outlines the regulatory mechanisms of mitochondrial homeostasis dysregulation at both the micro and macro levels， delves into the key role of mitochondrial homeostasis in VCI， analyzes potential therapeutic directions， and provides new scientific evidence and perspectives for the early diagnosis and treatment of VCI.

Key words: vascular cognitive impairment, mitochondrial homeostasis, mitochondrial biology, neuroprotection

CLC Number:

R471

Linghui DAI,Weifeng LI. Research progress on mitochondrial homeostasis in vascular cognitive impairment[J]. The Journal of Practical Medicine, 2025, 41(12): 1936-1944.

Figures/Tables 1

References 51

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