Abstract:

Objective To observe the ameliorating effect of EGCG on respiratory failure induced by hypoxiain rats with cor pulmonale. Methods Fifty rats were randomly divided into normal control group（normal oxygen+normal saline），model group（hypoxia+normal saline），low⁃dose EGCG group（hypoxia+10 mg/kg EGCG），high⁃dose EGCG group（hypoxia+50 mg/kg EGCG）and positive control group（hypoxia+1.0 mg/kg naloxone hydrochlo⁃ride），with 10 rats in each group. After 4 weeks of intervention，the lung function⁃related indexes，arterial bloodgas related indexes，serum interleukin⁃8（IL⁃8），and tumor necrosis factor⁃α（TNF⁃α）were detected. Hemody⁃namics and right heart index were detected. Results Compared with those in the normal control group，breathrate，peak expiratory flow rate（PEF），and 50% vital capacity maximum expiratory flow（FEF50），hydrogen ionconcentration（pH），oxygen partial pressure（PaO2），decreased，expiratory resistance，carbon dioxide partialpressure（PaCO2），serum interleukin⁃8（IL⁃8），tumor necrosis factor⁃α（TNF⁃α），average Pulmonary artery pres⁃sure（mPAP），and right heart index increased in model group，low⁃dose EGCG group，high⁃dose EGCG and posi⁃tive control group（P < 0.05）. Compared with those in the model group，breath rate，PEF，FEF50，pH，and PaO2level increased；but expiratory resistance，PaCO2，IL⁃8，TNF⁃ α，mPAP，and right heart index decreased inlow⁃dose EGCG group，high⁃dose EGCG and positive control group（P < 0.05）. Compared with those in the low⁃doseEGCG group，breath rate，PEF，FEF50，pH，and PaO2 level increased，while expiratory resistance，PaCO2，IL⁃8，TNF ⁃ α，mPAP，and right heart index decreased in high ⁃dose EGCG and positive control group（P < 0.05）.Conclusion EGCG can enhance pulmonary ventilation function induced by hypoxia in rats with cor pulmonale，which can diminish the inflammation response，reduce the right heart load，thus has good improvement effect onaspiration failure.

Key words: hypoxia, cor pulmonale, respiratory failure, EGCG, improvement effect