Abstract:

Objective To study the impact of latency period after preterm premature rupture of mem⁃ branes（PPROM）on early outcomes of preterm infants，and to provide reference for prenatal consultation and man⁃ agement of PPROM. Methods A total of 528 singleton preterm infants before 34 weeks′ gestation who were born after PPROM were enrolled between 2016 and 2019. Statistical analysis was performed for early outcomes of preterm infants. Results For preterm infants with PPROM before 28 weeks′ gestation，latency period after PPROM ≥ 7 d could reduce the total rate of severe morbidity，including moderate and severe bronchopulmonary dysplasia，necrotizing enterocolitis，severe retinopathy of prematurity，intraventricular hemorrhage（≥ grade 3）/ periventricular white matter；latency period ≥3 d could reduce the rate of severe retinopathy of prematurity（ROP） （P＜0.05）. No statistical difference was found in in⁃hospital mortality and rate of early⁃onset sepsis between differ⁃ ent latency period groups（P＞0.05）. For preterm infants with PPROM between 28~34 weeks′ gestation，no statisti⁃ cal difference was found in all the early outcomes between different latency period groups（P＞0.05）. Multivariate logistic regression analysis showed that a smaller gestational age at birth was an independent risk factor for in⁃hospi⁃ tal mortality，early⁃onset sepsis and severe morbidity（OR = 0.229，0.705 and 0.499 respectively，95%CI 0.092 ~ 0.570，0.617 ~ 0.805，0.432 ~ 0.576 respectively），Clinical chorioamnionitis was an independent risk factor for early ⁃onset sepsis（OR = 3.835，95%CI：1.797 ~ 8.181）. Conclusion Prolonged latency period after PPROM could increase gestational age and improve the early outcomes of preterm infants with gestational age＜34 weeks， but attention should be paid to clinical chorioamnionitis. Prolonged latency period to ≥ 7 d was advised for PPROM before 28 weeks′ gestation .

Key words:

preterm premature rupture of membranes（PPROM）, latency period, outcomes, early? onset sepsis, preterm infant ,