The Journal of Practical Medicine ›› 2025, Vol. 41 ›› Issue (13): 1958-1963.doi: 10.3969/j.issn.1006-5725.2025.13.003
• Symposiums • Previous Articles
Received:
2025-04-03
Online:
2025-07-10
Published:
2025-07-18
Contact:
Yajun TUO
E-mail:1134491856@qq.com
CLC Number:
Min CHEN,Yajun TUO. Research progress on renal injury associated with obstructive sleep apnea[J]. The Journal of Practical Medicine, 2025, 41(13): 1958-1963.
[1] |
YEGHIAZARIANS Y, JNEID H, TIETJENS J R, et al. Obstructive Sleep Apnea and Cardiovascular Disease: A Scientific Statement From the American Heart Association [J]. Circulation, 2021, 144(3): e56-e67. doi:10.1161/cir.0000000000000988
doi: 10.1161/cir.0000000000000988 |
[2] |
HERLIHY R, FRASSON DOS REIS L, GVRITISHVILI A, et al. Chronic intermittent hypoxia attenuates noradrenergic innervation of hypoglossal motor nucleus [J]. Respir Physiol Neurobiol, 2024, 321: 104206. doi:10.1016/j.resp.2023.104206
doi: 10.1016/j.resp.2023.104206 |
[3] |
CETIN-ATALAY R, MELITON A Y, TIAN Y, et al. Sustained hypoxia but not intermittent hypoxia induces HIF-1α transcriptional response in human aortic endothelial cells [J]. Mol Omics, 2025, 21(1): 19-31. doi:10.1039/d4mo00142g
doi: 10.1039/d4mo00142g |
[4] |
SANDERS A P, SACONI B, POLITIS M D, et al. Associations between obstructive sleep apnea and sleep characteristics with chronic kidney disease in rural Pennsylvania [J]. Sleep Med, 2024, 124: 70-76. doi:10.1016/j.sleep.2024.09.008
doi: 10.1016/j.sleep.2024.09.008 |
[5] |
WANG B, LI Z L, ZHANG Y L, et al. Hypoxia and chronic kidney disease [J]. EBio Med, 2022, 77: 103942. doi:10.1016/j.ebiom.2022.103942
doi: 10.1016/j.ebiom.2022.103942 |
[6] |
BONSIGNORE M R, MAZZUCA E, BAIAMONTE P, et al. REM sleep obstructive sleep apnoea [J]. Eur Respir Rev, 2024, 33(171) :230166. doi:10.1183/16000617.0166-2023
doi: 10.1183/16000617.0166-2023 |
[7] |
GLEESON M, MCNICHOLAS W T. Bidirectional relationships of comorbidity with obstructive sleep apnoea [J]. Eur Respir Rev, 2022, 31(164) :210256. doi:10.1183/16000617.0256-2021
doi: 10.1183/16000617.0256-2021 |
[8] |
MCNICHOLAS W T. Obstructive sleep apnoea and comorbidity- an overview of the association and impact of continuous positive airway pressure therapy [J]. Exp Rev Respir Med, 2019, 13(3): 251-261. doi:10.1080/17476348.2019.1575204
doi: 10.1080/17476348.2019.1575204 |
[9] |
HAN J, YE L, WANG Y. Pyroptosis: An Accomplice in the Induction of Multisystem Complications Triggered by Obstructive Sleep Apnea [J]. Biomolecules, 2024, 14(11) :1349. doi:10.3390/biom14111349
doi: 10.3390/biom14111349 |
[10] |
KELLY J T, SU G, ZHANG L, et al. Modifiable Lifestyle Factors for Primary Prevention of CKD: A Systematic Review and Meta-Analysis [J]. J Am Society Nephrol, 2021, 32(1): 239-253. doi:10.1681/asn.2020030384
doi: 10.1681/asn.2020030384 |
[11] |
WANG X, KIM C S, ADAMS B C, et al. Human proximal tubular epithelial cell-derived small extracellular vesicles mediate synchronized tubular ferroptosis in hypoxic kidney injury [J]. Redox Biol, 2024, 70: 103042. doi:10.1016/j.redox.2024.103042
doi: 10.1016/j.redox.2024.103042 |
[12] | 何燕, 崔赛仙, 胡阳, 等. 阻塞性睡眠呼吸暂停相关高血压患者尿钠排泄及影响因素研究[J]. 中国全科医学, 2025, 28(18): 2222-2227. |
[13] |
ABUYASSIN B, SHARMA K, AYAS N T, et al. Obstructive Sleep Apnea and Kidney Disease: A Potential Bidirectional Relationship?[J]. J Clin Sleep Med, 2015, 11(8): 915-924. doi:10.5664/jcsm.4946
doi: 10.5664/jcsm.4946 |
[14] |
RIMKE A N, AHMED S B, TURIN T C, et al. Effect of CPAP Therapy on Kidney Function in Patients With Chronic Kidney Disease: A Pilot Randomized Controlled Trial [J]. Chest, 2021, 159(5): 2008-2019. doi:10.1016/j.chest.2020.11.052
doi: 10.1016/j.chest.2020.11.052 |
[15] |
WANG S, CHENG Y, ZHANG Z, et al. Association between obstructive sleep apnea and chronic kidney disease: A cross-sectional and Mendelian randomization study [J]. Medicine, 2025, 104(6): e41437. doi:10.1097/md.0000000000041437
doi: 10.1097/md.0000000000041437 |
[16] |
SHIINA K. Obstructive sleep apnea-related hypertension: a review of the literature and clinical management strategy [J]. Hypertens Res, 2024, 47(11): 3085-3098. doi:10.1038/s41440-024-01852-y
doi: 10.1038/s41440-024-01852-y |
[17] |
张鹏, 张华, 胡扬喜, 等. 中国人内脏脂肪指数与肥胖合并阻塞性睡眠呼吸暂停的相关性及预测价值[J]. 实用医学杂志, 2023, 39(17): 2210-2214. doi:10.3969/j.issn.1006-5725.2023.17.010
doi: 10.3969/j.issn.1006-5725.2023.17.010 |
[18] |
GILDEH N, DRAKATOS P, HIGGINS S, et al. Emerging co-morbidities of obstructive sleep apnea: cognition, kidney disease, and cancer [J]. J Thor Dis, 2016, 8(9): E901-E17. doi:10.21037/jtd.2016.09.23
doi: 10.21037/jtd.2016.09.23 |
[19] |
AZARBARZIN A, ZINCHUK A, WELLMAN A, et al. Cardiovascular Benefit of Continuous Positive Airway Pressure in Adults with Coronary Artery Disease and Obstructive Sleep Apnea without Excessive Sleepiness [J]. Am J Respir Crit Care Med, 2022, 206(6): 767-774. doi:10.1164/rccm.202111-2608oc
doi: 10.1164/rccm.202111-2608oc |
[20] | 王小清, 胡文, 蔡菁菁, 等. 阻塞性睡眠呼吸暂停低通气综合征对肾脏损伤的研究进展[J]. 中国中西医结合耳鼻咽喉科杂志, 2019, 27(6): 475-479. |
[21] |
FAIVRE A, DE SEIGNEUX S. The role of hypoxia in chronic kidney disease: a nuanced perspective [J]. Curr Opin Nephrol Hypertens, 2024, 33(4): 414-419. doi:10.1097/mnh.0000000000000989
doi: 10.1097/mnh.0000000000000989 |
[22] |
SU Y, LI C, LIU W, et al. Comprehensive analysis of differentially expressed miRNAs in mice with kidney injury induced by chronic intermittent hypoxia [J]. Front Gene, 2022, 13: 918728. doi:10.3389/fgene.2022.918728
doi: 10.3389/fgene.2022.918728 |
[23] |
SHARMA S, HASHMI M F. Partial Pressure Of Oxygen [M]. StatPearls: Treasure Island (FL) ineligible companies, 2024. doi:10.5040/9781350525474.00000003
doi: 10.5040/9781350525474.00000003 |
[24] |
JACOBS M E, DE VRIES D K, ENGELSE M A, et al. Endothelial to mesenchymal transition in kidney fibrosis [J]. Nephrol Dial, Transpl, 2024, 39(5): 752-760. doi:10.1093/ndt/gfad238
doi: 10.1093/ndt/gfad238 |
[25] |
NAAS S, SCHIFFER M, SCHÖDEL J. Hypoxia and renal fibrosis [J]. Am J Physiol Cell Physiol, 2023, 325(4): C999-c1016. doi:10.1152/ajpcell.00201.2023
doi: 10.1152/ajpcell.00201.2023 |
[26] |
LIU J, LIVINGSTON M J, DONG G, et al. HIF-1 contributes to autophagy activation via BNIP3 to facilitate renal fibrosis in hypoxia in vitro and UUO in vivo [J]. Am J Physiol Cell Physiol, 2024, 326(3): C935-C947. doi:10.1152/ajpcell.00458.2023
doi: 10.1152/ajpcell.00458.2023 |
[27] |
DAENEN K, ANDRIES A, MEKAHLI D, et al. Oxidative stress in chronic kidney disease [J]. Pediatr Nephrol, 2019, 34(6): 975-991. doi:10.1007/s00467-018-4005-4
doi: 10.1007/s00467-018-4005-4 |
[28] |
ABOURJEILI J, SALAMEH E, NOUREDDINE M, et al. Obstructive sleep apnea: Beyond the dogma of obesity! [J]. Respir Med, 2024, 222: 107512. doi:10.1016/j.rmed.2023.107512
doi: 10.1016/j.rmed.2023.107512 |
[29] | 惠淼, 李月红. 阻塞性睡眠呼吸暂停相关肾损害机制[J]. 临床内科杂志, 2019, 36(9): 642-644. |
[30] |
MELIANTE P G, ZOCCALI F, CASCONE F, et al. Molecular Pathology, Oxidative Stress, and Biomarkers in Obstructive Sleep Apnea [J]. Int J Mol Sci, 2023, 24(6) :5478. doi:10.3390/ijms24065478
doi: 10.3390/ijms24065478 |
[31] | LU D, LI N, YAO X, et al. Potential inflammatory markers in obstructive sleep apnea-hypopnea syndrome [J]. Bosnian J Basic Med Sci, 2017, 17(1): 47-53. |
[32] |
KONG W, LIAO Y, ZHAO L, et al. Kidney Renin Release under Hypoxia and Its Potential Link with Nitric Oxide: A Narrative Review [J]. Biomedicines, 2023, 11(11) :2984. doi:10.3390/biomedicines11112984
doi: 10.3390/biomedicines11112984 |
[33] |
ZHAO Z B, MARSCHNER J A, IWAKURA T, et al. Tubular Epithelial Cell HMGB1 Promotes AKI-CKD Transition by Sensitizing Cycling Tubular Cells to Oxidative Stress: A Rationale for Targeting HMGB1 during AKI Recovery [J]. J Am Society Nephrol, 2023, 34(3): 394-411. doi:10.1681/asn.0000000000000024
doi: 10.1681/asn.0000000000000024 |
[34] |
NICHOLL D D, HANLY P J, POULIN M J, et al. Evaluation of continuous positive airway pressure therapy on renin-angiotensin system activity in obstructive sleep apnea [J]. Am J Respir Crit Care Med, 2014, 190(5): 572-580. doi:10.1164/rccm.201403-0526oc
doi: 10.1164/rccm.201403-0526oc |
[35] |
ZHANG J, CHEN Z, DENG Y, et al. Impacts of renal denervation on blood pressure in patients with obstructive sleep apnea [J]. Sleep Breathing, 2024, 28(5): 2135-2141. doi:10.1007/s11325-024-03130-0
doi: 10.1007/s11325-024-03130-0 |
[36] |
KHARAZMI F, HOSSEINI-DASTGERDI H, POURSHANAZARI A A, et al. The denervation or activation of renal sympathetic nerve and renal blood flow [J]. J Res Med Sci, 2023, 28: 76. doi:10.4103/jrms.jrms_216_23
doi: 10.4103/jrms.jrms_216_23 |
[37] |
KHARAZMI F, HOSSEINI-DASTGERDI H, POURSHANAZARI A A, et al. The denervation or activation of renal sympathetic nerve and renal blood flow [J]. J Res Med Sci, 2023, 28: 76. doi:10.4103/jrms.jrms_216_23
doi: 10.4103/jrms.jrms_216_23 |
[38] |
MAIER L E, MATENCHUK B A, VUCENOVIC A, et al. Influence of Obstructive Sleep Apnea Severity on Muscle Sympathetic Nerve Activity and Blood Pressure: a Systematic Review and Meta-Analysis [J]. Hypertens, 2022, 79(9): 2091-2104. doi:10.1161/hypertensionaha.122.19288
doi: 10.1161/hypertensionaha.122.19288 |
[39] |
WANG J, YE Y, SHANG Z, et al. Effect of norepinephrine reuptake inhibitors combined with antimuscarinic agents vs monotherapy for OSA: a systematic review and meta-analysis [J]. J Clin Sleep Med, 2024, 20(8): 1363-1372. doi:10.5664/jcsm.11130
doi: 10.5664/jcsm.11130 |
[40] |
WANG N, SU X, SAMS D, et al. P300/CBP Regulates HIF-1-Dependent Sympathetic Activation and Hypertension by Intermittent Hypoxia [J]. Am J Respir Cell Mol Biol, 2024, 70(2): 110-118. doi:10.1165/rcmb.2022-0481oc
doi: 10.1165/rcmb.2022-0481oc |
[41] |
GRASSI G, BIFFI A, SERAVALLE G, et al. Sympathetic nerve traffic overactivity in chronic kidney disease: a systematic review and meta-analysis [J]. J Hypertens, 2021, 39(3): 408-16. doi:10.1097/hjh.0000000000002661
doi: 10.1097/hjh.0000000000002661 |
[42] |
EVANS L C, DAYTON A, OSBORN J W. Renal nerves in physiology, pathophysiology and interoception [J]. Nat Rev Nephrol, 2025, 21(1): 57-69. doi:10.1038/s41581-024-00893-3
doi: 10.1038/s41581-024-00893-3 |
[43] |
LIN C H, LURIE R C, LYONS O D. Sleep Apnea and Chronic Kidney Disease: A State-of-the-Art Review [J]. Chest, 2020, 157(3): 673-685. doi:10.1016/j.chest.2019.09.004
doi: 10.1016/j.chest.2019.09.004 |
[44] |
HARKI O, TAMISIER R, PÉPIN J L, Et al. VE-cadherin cleavage in sleep apnoea: new insights into intermittent hypoxia-related endothelial permeability [J]. Eur Respir J, 2021, 58(4) :2004518. doi:10.1183/13993003.04518-2020
doi: 10.1183/13993003.04518-2020 |
[45] |
PERACAULA M, TORRES D, POYATOS P, et al. Endothelial Dysfunction and Cardiovascular Risk in Obstructive Sleep Apnea: A Review Article [J]. Life, 2022, 12(4) :537. doi:10.3390/life12040537
doi: 10.3390/life12040537 |
[46] |
FUJISAWA T, TURA-CEIDE O, HUNTER A, et al. Endothelial Progenitor Cells Do Not Originate From the Bone Marrow [J]. Circulation, 2019, 140(18): 1524-1526. doi:10.1161/circulationaha.119.042351
doi: 10.1161/circulationaha.119.042351 |
[47] |
MURRI M, GARCíA-DELGADO R, ALCáZAR-RAMíREZ J, et al. Effect of CPAP on oxidative stress and circulating progenitor cell levels in sleep patients with apnea-hypopnea syndrome [J]. Respir Care, 2011, 56(11): 1830-6. doi:10.4187/respcare.01081
doi: 10.4187/respcare.01081 |
[48] |
SHANG F, WANG S C, GONGOL B, et al. Obstructive Sleep Apnea-induced Endothelial Dysfunction Is Mediated by miR-210 [J]. Am J Respir Crit Care Med, 2023, 207(3): 323-335. doi:10.1164/rccm.202202-0394oc
doi: 10.1164/rccm.202202-0394oc |
[49] | EAN-LOUIS G, ZIZI F, CLARK L T, et al. Obstructive sleep apnea and cardiovascular disease: role of the metabolic syndrome and its components [J]. J Clin Sleep Med, 2008, 4(3): 261-272. |
[50] |
王微, 张荣丽, 凌继祖, 等. 内质网应激导致间歇低氧模型大鼠肾脏损伤的机制及洛沙坦的干预作用[J]. 中国呼吸与危重监护杂志, 2020, 19(6): 592-597. doi:10.7507/1671-6205.201901009
doi: 10.7507/1671-6205.201901009 |
[51] |
BEAUDIN A E, RANERI J K, AHMED S B, et al. Risk of chronic kidney disease in patients with obstructive sleep apnea [J]. Sleep, 2022, 45(2) :zsab267. doi:10.1093/sleep/zsab267
doi: 10.1093/sleep/zsab267 |
[52] |
CHANG S W, KANG J W. Increasing obstructive sleep apnea risk is associated with albuminuria in Korean adults: cross-sectional analysis [J]. Sci Rep, 2024, 14(1) :6676. doi:10.1038/s41598-024-57394-3
doi: 10.1038/s41598-024-57394-3 |
[53] |
ZHANG F, HUANG X, WANG H, et al. Prevalence of obstructive sleep apnea in whole spectrum chronic kidney disease patients: A systematic review and meta-analysis [J]. Sleep Med, 2024, 119: 526-34. doi:10.1016/j.sleep.2024.05.047
doi: 10.1016/j.sleep.2024.05.047 |
[54] | 付卓志, 吴亚岑, 李媚希, 等. 阻塞性睡眠呼吸暂停严重度评估参数及诊断技术[J]. 生物化学与生物物理进展, 2025, 52(1): 147-161. |
[55] | 王凤梅, 刘必成. 慢性肾脏病防治的新纪元[J]. 中国实用内科杂志, 2025, 45(3): 177-182. |
[56] |
ZHANG H, ZHANG Z, ZHAO Y, et al. Association of the combination of obstructive sleep apnea risk and sleep duration with ideal cardiovascular health metrics in patients undergoing hemodialysis [J]. BMC Nephrol, 2024, 25(1): 77. doi:10.1186/s12882-024-03517-x
doi: 10.1186/s12882-024-03517-x |
[57] | 马晓蓉, 张静宜, 宗运之, 等. 无创呼吸机治疗对阻塞性睡眠呼吸暂停低通气综合征患者骨钙素和认知功能障碍的影响 [J]. 实用医学杂志, 2023, 39(2): 249-254. |
[58] |
ZAMARRÓN E, JAUREGUIZAR A, GARCÍA-SÁNCHEZ A, et al. Continuous Positive Airway Pressure Effect on Albuminuria Progression in Patients with Obstructive Sleep Apnea and Diabetic Kidney Disease: A Randomized Clinical Trial [J]. Am J Respir Crit Care Med, 2023, 207(6): 757-767. doi:10.1164/rccm.202206-1091oc
doi: 10.1164/rccm.202206-1091oc |
[59] |
HANLY P J, UNRUH M L. Continuous Positive Airway Pressure Therapy for Chronic Kidney Disease in Patients with Obstructive Sleep Apnea: The Jury Is Still Out [J]. Am J Respir Crit Care Med, 2023, 207(6): 657-659. doi:10.1164/rccm.202211-2171ed
doi: 10.1164/rccm.202211-2171ed |
[60] |
CHEN Y, CHEN R, LIN Y, et al. Treatment of Obstructive Sleep Apnea and Diabetic Kidney Disease: Can Continuous Positive Airway Pressure Reduce Albuminuria Progression? [J]. Am J Respir Crit Care Med, 2023, 207(7): 955-956. doi:10.1164/rccm.202211-2173le
doi: 10.1164/rccm.202211-2173le |
[61] | 张童, 魏丽娟, 严梅. 管理模式对阻塞性睡眠呼吸暂停患者依从性的影响 [J]. 世界睡眠医学杂志, 2022, 9(5): 962-964. |
[62] |
WARCHOL-CELINSKA E, PREJBISZ A, KADZIELA J, et al. Renal Denervation in Resistant Hypertension and Obstructive Sleep Apnea: Randomized Proof-of-Concept Phase Ⅱ Trial [J]. Hypertens, 2018, 72(2): 381-390. doi:10.1161/hypertensionaha.118.11180
doi: 10.1161/hypertensionaha.118.11180 |
[63] |
GOTTLIEB D J, PUNJABI N M. Diagnosis and Management of Obstructive Sleep Apnea: A Review [J]. JAMA, 2020, 323(14): 1389-1400. doi:10.1001/jama.2020.3514
doi: 10.1001/jama.2020.3514 |
[64] | 钟榕槟, 饶明聪, 黄敏方. 口腔矫治器治疗阻塞性睡眠呼吸暂停与失眠共病的疗效[J]. 实用医学杂志, 2023, 39(1): 92-96. |
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