Abstract:

Objective To investigate the effects of natural orifice specimen extraction（NOSE）in laparo⁃ scopic colorectal cancer（CRC）surgery on bacterial contamination and dissemination of exfoliated tumor cells. Methods Eligible patients were randomly assigned to two groups：the traditional laparoscopic surgery group and the laparoscopic with NOSE group. Related indicators were compared. Results 92 patients were enrolled in the study. There were no significant differences in bacterial culture and the positive rate of free tumor cells in the perito⁃ neal lavage fluids at the beginning and the end of the surgery between the two groups，and the comparisons within each group were statistically significant（P < 0.05）. There was no significant difference in the positive rate of free tumor cells in the intestinal lavage fluids before and after anastomosis between the two groups and within each group. The follow⁃up time was 3 ~ 53 months. There were no significant differences between the two groups in the local relapse ⁃ free survival（LRFS），nodal relapse ⁃ free survival（NRFS），and distant metastasis ⁃ free survival （DMFS）. Conclusion Compared with traditional laparoscopic surgery，NOSE showed no significant differences in terms of bacterial contamination at the surgical area，exfoliation and implantation of tumor cells during surgery， and tumor recurrence and dissemination.

Key words:

natural orifice specimen extraction, laparoscopic, colorectal cancer

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