Abstract:

Objective To investigate the effects of intestinal microflora on the peritonitis therapeutic effect and prognosis of elderly patients with liver cirrhosis. Methods All patients were divided into the study group and the control group. To begin with，propensity score matching method was used to match the clinical factors between the two groups before treatment，and the samples with balanced clinical factors before treatment were obtained，then，two independent samples t⁃test was used to compare the peritonitis treatment effect between the two matched groups，furthermore，Cox regression model was used to evaluate the effect of the study group on peritonitis treatment time and liver cirrhosis progression free survival. Finally，Kaplan⁃Meier survival analysis was used to compare abdominal distension，ascites duration cumulative rate and liver cirrhosis free progression survival rate between the two matched groups，P < 0.05，the difference was statistically significant. Results A total of 240 elderly cirrhotic peritonitis patients were enrolled and divided into study⁃ and control group according to differ⁃ ent treatment. Using propensity score matching method，a total of 61 pairs of the two groups were successfully matched. After matching，the liver function and peritonitis indexes of the study group were significantly better than those of the control group after 2 weeks of peritonitis treatment，Cox regression model showed the peritonitis treat⁃ ment time of the study group was significantly shortened（HR：0.62；95% CI：0.35 ~ 0.98；P < 0.05），and the liver cirrhosis free progression survival time of the study group was significantly higher than that of the control group（HR：0.58；95% CI：0.35 ~ 0.98；P < 0.05）；95% CI：0.39 ~ 0.72；P < 0.05）. Kaplan⁃Meier survival analysis showed the lasted for 8 days，10 days and 14 days abdominal distension and ascites accumulation rate in the study group were significantly lower than those in the control group（75.3% ，48.6% ，22.4% vs. 90.2% ， 83.4%，28.2%，P < 0.05）；the 6⁃month，1⁃year，2⁃year liver cirrhosis free progression survival rate in the study group was significantly higher than that in the control group（90.2%，78.1%，23.8% vs 75.2%，54.3%，11.6%， P < 0.05）. Conclusion Probiotics has obvious therapeutic effect on elderly patients with liver cirrhosis complicated with spontaneous peritonitis，at the same time it can prevent liver disease from becoming severe，prolong the liver cirrhosis free progression survival time ，and make patients obtain clinical benefits.

Key words: