长链非编码RNA（long non⁃coding RNA，lncRNA）是一种多功能的非编码RNA，参与调控多种 肿瘤的进展。糖原合酶激酶⁃3β（glycogen synthase kinase⁃3β，GSK⁃3β）是一种丝氨酸和苏氨酸激酶，通过Wnt/ β⁃catenin、PI3K/Akt、Notch、NF⁃κB和Hedgehog信号通路发挥重要的肿瘤调控作用。近年来不断有研究表明 lncRNA与GSK⁃3β相关通路的相互作用在多种肿瘤中发挥着重要作用，与患者预后密切相关。本文对lncRNA 与GSK⁃3β相关通路在多种肿瘤中的作用进行综述，以期为临床治疗及未来研究提供借鉴和思考。

Long non⁃coding RNA（lncRNA）is a multifunctional non⁃coding RNA involving in the regula⁃ tion of the development of a variety of tumors. GSK⁃3β is a serine and threonine kinase that plays an important role in tumor regulation through Wnt/β⁃catenin，PI3K/Akt，Notch，NF⁃κB and Hedgehog signaling pathways. In recent years，increasing studies have shown that the interactions between lncRNA and GSK⁃3β related signaling pathways play an important role in various tumors and are closely related to patient prognosis. In this paper，the roles of lncRNA and GSK ⁃ 3β related signaling pathways in various tumors are reviewed，so as to provide reference and thinking for clinical treatment and future research.