目的 应用磁敏感加权成像（SWI）测量针刺治疗帕金森病患者的黑质致密带（SNc）变化，无创性地评价针刺治疗帕金森病的疗效。方法 选择 2020 年 5-12 月在我院行针刺治疗的 50 例帕金森病患 者，治疗 3 个疗程后根据其治疗效果不同分为治愈组、缓解组和无效组。所有患者在治疗前、治疗 3 个疗 程后均进行 MRI 检查，采用 SWI 序列扫描，测量其 SNc 宽度、中脑直径比值、SN 面积，比较各组检查结果。 结果 三组针刺治疗前的 SNc 宽度、SN 面积、中脑直径、SNc/中脑直径比值对比差异无统计学意义（P > 0.05）。治疗 3 个疗程后，治愈组、缓解组的 SNc 宽度、SN 面积、中脑直径、SNc/中脑直径比值显著低于治疗前（P < 0.05），而无效组治疗前后的 SNc 宽度、SN 面积、中脑直径、SNc/中脑直径比值比较差异无统计学意 义（P > 0.05）。治疗后治愈组的 SNc 宽度、SN 面积、中脑直径、SNc/中脑直径比值明显低于缓解组和无效 组（P < 0.05）。结论 磁敏感加权成像检查可清楚显示帕金森病患者黑质致密带大小变化，其应用于针 刺治疗帕金森患者治疗效果判断中具有较高的价值。

Objective To evaluate the therapeutic effect of acupuncture on Parkinson′s disease by measur⁃ ing the changes of substantia nigra dense zone（SNC）with susceptibility weighted imaging（SWI）. Methods 50 cases of patients with Parkinson′s disease who were treated with acupuncture in our hospital from May 2020 to December 2020 were selected. After 3 months of treatment，they were divided into cure group，remission group and ineffective group according to their therapeutic effects. All patients underwent MRI examination before and after 3 courses of treatment. SWI sequence scanning was used to measure the SNC width，midbrain diameter ratio and Sn area. Results There were no significant differences in SNC width，Sn area，midbrain diameter and SNC/ midbrain diameter ratio among the three groups before acupuncture treatment（P > 0.05）. After 3 courses of treat⁃ ment，the SNC width，Sn area，midbrain diameter and SNC/midbrain diameter ratio of the cured group and remis⁃ sion group were significantly lower than those before treatment（P < 0.05），while there were no significant differ⁃ ences in SNC width，SN area，midbrain diameter and SNC/midbrain diameter ratio of the ineffective group before and after treatment（P > 0.05）. After treatment，the SNC width，SN area，midbrain diameter and SNC/midbrain diameter ratio of the cured group were significantly lower than those of the remission group and the ineffective group （P < 0.05）. Conclusion Susceptibility weighted imaging can clearly show the size change of substantia nigra dense zone in patients with Parkinson′s disease，and it has high value in judging the therapeutic effect of acupunc⁃ ture in patients with Parkinson′s disease.