Progress in mechanism and targeted therapy of immune kidney disease mediated by complement
Received date: 2025-08-13
Online published: 2026-03-09
余剑梅 , 何伟春 . 补体介导免疫性肾病的机制与靶向治疗进展[J]. 实用医学杂志, 2026 , 42(5) : 899 -908 . DOI: 10.3969/j.issn.1006-5725.2026.05.023
Atypical hemolytic uremic syndrome （aHUS） and C3 glomerulopathy （C3G） are well-recognized complement-mediated kidney diseases. In recent years， an increasing body of evidence has demonstrated that the complement system plays a pivotal role in the pathogenesis of various immune-mediated kidney diseases， such as IgA nephropathy， membranous nephropathy （MN）， lupus nephritis （LN）， antineutrophil cytoplasmic antibody-associated vasculitis （AAV）， and anti-glomerular basement membrane disease （anti-GBM disease）. Although current immunosuppressive therapies and corticosteroids can partly control disease progression， these agents are frequently associated with severe adverse effects， and a portion of patients show suboptimal therapeutic responses. Therefore， the development of novel therapeutic strategies is an urgent necessity. Complement-targeted therapies have emerged as a research focus， providing new avenues for the treatment of immune-mediated kidney diseases. This review summarizes recent advancements in this field.
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