收稿日期: 2025-04-15
网络出版日期: 2025-09-25
基金资助
国家自然科学基金青年基金资助项目(82104973);河南省中医药科学研究专项(20-21ZY1017);河南省中医药传承与创新人才工程（仲景工程）-拔尖人才(CZ0325-14);河南省中医学“双一流”创建科学研究专项(HSRP-DFCTCM-2023-3-11)
Modulation of microglia by traditional Chinese medicine improves post⁃stroke depression
Received date: 2025-04-15
Online published: 2025-09-25
李琪 , 高静 , 张铭 , 张栩 , 冯雅琛 , 潘蕊 , 王春晓 , 任琼迪 . 中药调控小胶质细胞改善卒中后抑郁的研究进展[J]. 实用医学杂志, 2025 , 41(18) : 2945 -2952 . DOI: 10.3969/j.issn.1006-5725.2025.18.023
Post-stroke depression （PSD）， a common stroke complication characterized by depressed mood and diminished interest， severely affects patients' recovery and quality of life. Microglial abnormal activation and polarization play key roles in PSD pathogenesis， closely associated with neuroinflammation and imbalance in neurotransmitter metabolism. In contrast， traditional Chinese medicine （TCM） demonstrates unique multi-target and multi-level mechanisms： regulating microglial function， ameliorating post-stroke neuroinflammatory environments， and promoting neuroplasticity， thereby potentially alleviating PSD symptoms. This review summarizes TCM's effects on microglial activation/polarization states and its therapeutic advances in PSD， providing novel perspectives and strategies for clinical management.
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