收稿日期: 2025-05-22
网络出版日期: 2025-09-05
基金资助
国家自然科学基金资助项目(82103752)
Research progress on the phototherapy in vitiligo
Received date: 2025-05-22
Online published: 2025-09-05
高榕荫 , 万聪翀 , 殷川伟 , 吕金鹏 . 光疗在白癜风治疗中的研究进展[J]. 实用医学杂志, 2025 , 41(17) : 2646 -2652 . DOI: 10.3969/j.issn.1006-5725.2025.17.006
Phototherapy plays a significant role in vitiligo treatment. Narrow-band ultraviolet B （NB-UVB） remains the first-line phototherapy for non-segmental vitiligo in clinical practice. In recent years， visible light has emerged as a novel therapeutic approach for vitiligo. Studies indicate that helium-neon laser demonstrates superior efficacy in segmental vitiligo， blue light is more effective for localized vitiligo， and NB-UVB is better suited for generalized or extensive vitiligo. Different phototherapy modalities exhibit distinct mechanisms of action， involving multiple biological proteins and signaling pathways in melanocyte activation and repigmentation. This review summarizes recent advances in phototherapy for vitiligo treatment.
Key words： vitiligo; phototherapy; NB-UVB; helium-neon laser; blue light
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