目的 探讨上颌前牵引联合个性化钛板治疗生长发育期骨性Ⅲ类错的临床效果。 方法 纳入2021年5月至2023年5月本院收治的96例生长发育期骨性Ⅲ类错患者，采用随机数字表法分组，奇数为对照组（n = 48），偶数为观察组（n = 48），对照组予以上颌前牵引治疗，观察组予以上颌前牵引联合个性化钛板治疗，比较两组临床疗效、颌面部软组织指标（LL-EP、NLA、G-SnPg）、硬组织指标［上牙槽座角（SNA）、下牙槽座角（SNB）、上下牙槽座角（ANB）、下颌平面角度（MP-SN）、颌平面与眶耳平面（FH）角度（MP-FH）、上颌骨位置（A-OLP）、下颌骨位置（Pg-OLP）、Y轴角度（Y轴角）］、舌骨位置、牙性指标［H-X、H-Y、H-MP、H-FH］及不良反应发生情况。 结果 治疗后，观察组治疗总有效率较对照组高（P < 0.05）；观察组LL-EP较对照组小（P < 0.05）；观察组SNA、ANB、MP-SN、MP-FH、A-OLP及Y轴角均较对照组大（P < 0.05）；观察组H-X、H-Y较对照组大（P < 0.05）；观察组U1-NA较对照组大，覆较对照组短（P < 0.05）；两组不良反应发生情况无显著差异（P > 0.05）。 结论 上颌前牵引联合个性化钛板治疗可显著提升骨性Ⅲ类错患者的临床疗效，改善软硬组织结构、舌骨位置及牙性指标，且安全性良好。

Objective To investigate the clinical efficacy of maxillary protraction combined with customized titanium plates in the treatment of skeletal Class Ⅲ malocclusion during the growth and development stage. Methods A total of 96 patients diagnosed with skeletal Class Ⅲ malocclusion who received treatment at our hospital between May 2021 and May 2023 were included in this study. Participants were randomly divided into two groups using a ball-drawing method： those assigned odd numbers were placed in the control group （n = 48）， while those assigned even numbers were allocated to the experimental group （n = 48）. The control group underwent maxillary protraction therapy alone， whereas the experimental group received maxillary protraction combined with customized titanium plate intervention. The two groups were evaluated and compared based on clinical effectiveness， facial soft tissue parameters （LL-EP， NLA， G-SnPg）， hard tissue parameters ［SNA （sella-nasion-A point angle）， SNB （sella-nasion-B point angle）， ANB （A point-nasion-B point angle）， MP-SN （mandibular plane-SN angle）， MP-FH （mandibular plane-Frankfort horizontal angle）， A-OLP （vertical distance from A point to occlusal line plane）， Pg-OLP （vertical distance from pogonion to OLP）， and Y-axis angle］， hyoid bone position， dental indicators （H-X， H-Y， H-MP， H-FH）， and the incidence of adverse events. Results Following the intervention， the experimental group demonstrated a significantly higher overall efficacy rate compared to the control group （P < 0.05）. The LL-EP value was significantly lower in the experimental group （P < 0.05）； conversely， SNA， ANB， MP-SN， MP-FH， A-OLP， and the Y-axis angle were all significantly increased （P < 0.05）. Additionally， H-X and H-Y distances were notably shorter （P < 0.05）， while U1-NA was greater and overbite depth was reduced in comparison to the control group （P < 0.05）. No statistically significant difference was observed in the incidence of adverse reactions between the two groups （P > 0.05）. Conclusion Maxillary protraction utilizing customized titanium plates can significantly improve clinical outcomes in patients with skeletal Class Ⅲ malocclusion， positively affecting both craniofacial hard and soft tissue structures， hyoid bone positioning， and dental parameters， while maintaining a favorable safety profile.