收稿日期: 2024-01-14
网络出版日期: 2024-11-05
基金资助
国家自然科学基金项目(82071500);上海市“科技创新行动计划”优秀学科带头人项目(21XD1423300);上海市浦江人才计划(21PJD063)
Advances in oxidative stress⁃related pathways with diagnostic and predictive value in schizophrenia
Received date: 2024-01-14
Online published: 2024-11-05
俞天悦 , 郭茜 , 胡昊 , 苏宇静 , 陈剑华 . 精神分裂症中氧化应激相关通路与诊断和预测价值的研究进展[J]. 实用医学杂志, 2024 , 40(20) : 2935 -2940 . DOI: 10.3969/j.issn.1006-5725.2024.20.019
Schizophrenia is a severe mental illness with a significant disease burden. The interaction between oxidative stress and pro-inflammatory factors promotes chronic neuroinflammation and immune damage， leads to dysregulation of dopaminergic and glutamatergic pathways and occurrence of psychotic symptoms and is believed to be closely related to the pathogenesis of schizophrenia. In this paper， we aim to identify biomarkers within the tryptophan kynurenine metabolic pathway， the WNT/β-Catenin pathway and the NF-κB pathway， and dopamine metabolism. These pathways have been extensively studied and are known to be involved in the interaction between inflammation and oxidative stress. We will also explore the potential application of related antioxidants in the diagnosis and treatment of schizophrenia， summarizing their current research progress.
Key words： oxidative stress; inflammatory factor; schizophrenia; biomarker
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