收稿日期: 2024-02-20
网络出版日期: 2024-08-26
基金资助
贵州省科技计划项目（编号：黔科合支撑［2021］一般451）;中华国际医学交流基金会2021SKY影像科研基金(Z-2014-07-2101)
Analysis of global local consistency changes in first-episode depression with childhood maltreatment based on resting-state magnetic resonance
Received date: 2024-02-20
Online published: 2024-08-26
目的 利用静息态磁共振成像（resting state-fMRI， rs-fMRI）探讨抑郁症伴有童年期创伤患者大脑局部一致性改变，并与童年创伤的严重程度进行相关分析。 方法 纳入25例抑郁症伴童年创伤患者，25例抑郁症不伴童年创伤患者，以及25例年龄、性别、教育水平匹配的健康对照组。所有被试均进行rs-fMRI扫描和ReHo分析，使用单因素方差分析比较其组间差异并进行多重比较校正。使用Pearson相关分析探索抑郁症伴童年创伤异常脑区ReHo值与临床量表的关系。 结果 与抑郁症不伴童年创伤组相比，抑郁症伴童年创伤组的异常脑区主要位于背外侧前额叶皮层、小脑、顶上小叶及中央前回（体素水平P < 0.05，团块水平P < 0.01，GRF 校正）。抑郁症伴童年创伤左侧小脑半球（P = 0.006，r = 0.523）、左背外侧前额叶皮层（P = 0.001，r = 0.662）的ReHo值与童年创伤严重程度具有相关性。 结论 抑郁症伴童年创伤存在自发性脑活动改变，并与童年创伤严重程度具有相关性，背外侧前额叶及小脑功能改变可能解释抑郁症伴童年创伤的神经生物学机制。
王頔 , 廖旦 , 刘远成 , 徐睿 , 段庆红 . 基于静息态磁共振分析首发抑郁症伴童年创伤全脑局部一致性变化[J]. 实用医学杂志, 2024 , 40(16) : 2311 -2315 . DOI: 10.3969/j.issn.1006-5725.2024.16.018
Objective This study used resting-state functional magnetic resonance imaging （rs-fMRI） to investigate the changes of local brain regional homogeneity in patients with depression and childhood maltreatment， and we calculated the relationship between altered ReHo values and the severity of childhood maltreatment. Methods 25 patients with depression and childhood maltreatment， 25 patients with depression without childhood maltreatment， and 25 age， gender， and education-matched healthy controls were prospectively enrolled. All subjects underwent resting-state functional magnetic resonance imaging and ReHo analysis. One-way analysis of variance was used to compare the group differences， along with multiple comparison correction. Pearson correlation analysis was used to explore the relationship between region ReHo values with clinical scales. Results Compared with the group of depression without childhood maltreatment， the abnormal brain regions of depression with childhood maltreatment are mainly located in the dorsolateral prefrontal cortex， cerebellum， parietal gyrus， and precentral gyrus. The ReHo values of depression with childhood maltreatment in the left cerebellum and the left dorsolateral prefrontal cortex are correlated with the severity of childhood maltreatment. Conclusions Depression with childhood maltreatment is associated with changes in local spontaneous brain activity， which are correlated with the severity of childhood maltreatment. The brain changes in the dorsolateral prefrontal cortex and cerebellum may explain the neurobiological mechanisms of depression with childhood maltreatment.
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