目的 分析参加肺癌早期筛查者风险及相关影响因素，并根据生存情况研究预后因素，以期最终为肺癌防治提供基线数据。 方法 采取整群抽样的方法，选取2020年郑州市10区6县40 ~ 75岁郑州市户籍居民为筛查对象，通过自愿参加并填写评估问卷， 评估出肺癌高危人群，再对高危人群行复筛三项（肿瘤标志物、低剂量螺旋CT及肺功能）检查。最后采取主动加被动随访方式收集确诊肺癌患者信息。对筛查的数据进行统计描述，表述不同特征人群流行病学结果；采用多因素logistic回归方法进行统计分析，比较不同因素各项结果差异。 结果 2020年郑州市肺癌早期筛查完成评估50 128例，完成率100.26%，调查平均年龄（59.86 ± 17.67）岁，男女比例为0.81∶1。其中高危检出率为30.15%。多因素logistic回归分析显示：男性（吸烟）（OR = 5.43，95%CI：5.20 ~ 5.67）、有烟草接触史（OR = 3.82，95%CI：3.67 ~ 3.98）、一级亲属曾患肺癌（OR = 12.06，95%CI：11.02 ~ 13.20）等人群更易患肺癌（均P < 0.05）。 结论 男性（吸烟）、接触二手烟、一级亲属患癌、曾经确诊其他肿瘤、肺部感染症状、“日常生活中出现胸闷，气促，呼吸困难”、“近3年内曾经受较大的精神创伤”因素是肺癌高危的独立危险因素，应重点关注并加以有效干预措施。

Objective To analyze the risks and related influencing factors of early screening for lung cancer， and to study prognostic factors based on survival conditions， in order to ultimately provide baseline data for the prevention and treatment of lung cancer. Methods A cluster sampling method was used to select 40 to 75 year old registered residence residents in 10 districts and 6 counties of Zhengzhou City in 2020 as screening objects. Through voluntary participation and filling in evaluation questionnaires， high-risk groups of lung cancer were evaluated， and then three screening tests （tumor markers， low-dose spiral CT and lung function） were performed on high-risk groups. Finally， we will adopt an active and passive follow-up approach to collect information on diagnosed lung cancer patients. Statistically describe the screening data and describe the epidemiological results of different characteristic populations； Using multivariate logistic regression method for statistical analysis， compare the differences in various results of different factors. Results 50 128 cases of early screening for lung cancer in Zhengzhou City were evaluated in 2020， with a completion rate of 100.26%. The average age of the survey was （59.86 ± 17.67） years old， and the gender ratio was 0.81∶1. The high-risk detection rate is 30.15%. Multivariate logistic regression analysis showed that males （smoking） （OR = 5.43， 95% CI： 5.20 ~ 5.67）， individuals with a history of tobacco exposure （OR = 3.82， 95% CI： 3.67 ~ 3.98）， first-degree relatives who had previously suffered from lung cancer （OR = 12.06， 95% CI： 11.02 ~ 13.20）， and other populations were more susceptible to lung cancer （all P < 0.05）. Conclusion Male （smoking）， exposure to secondhand smoke， cancer in first-degree relatives， previous diagnosis of other tumors， symptoms of lung infection， “chest tightness， shortness of breath， and difficulty breathing in daily life”， and “significant psychological trauma in the past 3 years” are independent risk factors for lung cancer， which should be given special attention and effective intervention measures should be taken.