专题笔谈

深度学习在辅助生殖技术领域的应用进展

  • 胡希 ,
  • 李艳 ,
  • 刘洋
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  • 昆明医科大学第二附属医院生殖医学科 (昆明 650101 )
刘洋,医学博士、主任医师、硕士研究生导师,昆明医科大学第二附属医院生殖医学科副主任。中国优生科学协会生殖道疾病临床诊治分会委员,云南省医师协会临床精准医疗专业委员会副主任委员,云南省女医师协会妇科分会副主任委员,云南省优生优育妇幼保健协会助孕与优生专业委员会副主任委员,云南省医师协会医学遗传学分会副主任委员。首批云南省万人计划“青年拔尖人才”,云南省“兴滇英才支持计划”名医项目,云南省卫健委医学学科带头人,云南省优秀青年骨干教师,国家级生殖健康咨询师,获云南省卫生科技教育管理协会科技进步二等奖、三等奖等,主持国家级、省厅级课题近十项,发表SCI论文数十余篇(累计影响因子89.64),中文核心期刊论文近百篇,获批实用新型专利12项,发表专著3部。E-mail:13518735544@163.com

收稿日期: 2023-11-13

  网络出版日期: 2024-04-08

基金资助

云南省兴滇英才支持计划名医项目(XDYC- MY-2022-0057);云南省专业学位研究生教学案例库(20208007);昆明医科大学中青年学科带头人及后备人选-“乘风”人才培养计划(2023(108))

Recent advances on the application of deep learning in assisted reproductive technology

  • Xi HU ,
  • Yan LI ,
  • Yang. LIU
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  • Department of Reproductive Medicine,the Second Affiliated Hospital of Kunming Medical University,Kunming 650101,China

Received date: 2023-11-13

  Online published: 2024-04-08

摘要

深度学习是人工智能领域一种机器学习方法,它模拟人类大脑神经网络的工作原理来解决复杂的问题,目前在医学领域已有许多重要的研究和应用,如影像诊断、生物医学数据处理、药物研发、个性化医疗等,提高了医疗诊断和治疗的准确性及效率。在辅助生殖领域,深度学习在干预过程中高效识别生长良好的胚胎、适宜的卵母细胞或精子,协助专业人员做出更为准确的选择,提高妊娠率,减少多胎妊娠风险。本文将综合归纳近5年深度学习在辅助生殖技术领域的最新应用进展,并对今后研究方向进行展望。

本文引用格式

胡希 , 李艳 , 刘洋 . 深度学习在辅助生殖技术领域的应用进展[J]. 实用医学杂志, 2024 , 40(7) : 893 -897 . DOI: 10.3969/j.issn.1006-5725.2024.07.003

Abstract

Deep learning is a machine learning method in the field of artificial intelligence, which simulates the workings of the neural network of the human brain to solve complex problems, and has been used in many important researches and applications in the field of medicine, such as diagnostic imaging, biomedical data processing, drug research and development, personalized medicine, etc., which improves the accuracy and efficiency of diagnosis and treatment. In the field of assisted reproduction, deep learning could efficiently identify well-grown embryos, suitable oocytes, or sperms during the intervention process, assisting medical staff to make more accurate choices to improve pregnancy rates and reduce the risk of multiple pregnancies. This paper summarizes the latest advances in the application of deep learning in the field of assisted reproduction technology in the past 5 years, and provides an outlook for future research.

参考文献

1 BI W L, HOSNY A, SCHABATH M B,et al. Artificial intelligence in cancer imaging: Clinical challenges and applications[J]. CA Cancer J Clin, 2019,69(2):127-157. doi:10.3322/caac.21552
2 周德富,邹廉,陈瑛. 人工神经网络在体外受精胚胎评估中的应用[J]. 中华检验医学杂志, 2022,45(3): 310-314. doi:10.3760/cma.j.cn114452-20210811-00496
3 于医萍,高一博,方兰兰,等. 机器学习在体外受精-胚胎移植技术中的应用[J]. 中华生殖与避孕杂志, 2021,41(10): 883-892. doi:10.3760/cma.j.cn101441-20200428-00251
4 GARDNER D K, LANE M, STEVENS J,et al. Reprint of: Blastocyst score affects implantation and pregnancy outcome: towards a single blastocyst transfer[J]. Fertil Steril,2019,112(4 ):e81-e84. doi:10.1016/j.fertnstert.2019.08.077
5 MUSHTAQ A, MUMTAZ M, RAZA A,et al. Artificial Intelligence-Based Detection of Human Embryo Components for Assisted Reproduction by In Vitro Fertilization[J]. Sensors, 2022,22(19): 7418. doi:10.3390/s22197418
6 CHAVEZ-BADIOLA A, FLORES-SAIFFE-FARíAS A, MENDIZABAL-RUIZ G, et al. Embryo Ranking Intelligent Classification Algorithm(ERICA): artificial intelligence clinical assistant predicting embryo ploidy and implantation[J]. Reprod Biomed Online, 2020, 41(4): 585-593. doi:10.1016/j.rbmo.2020.07.003
7 ORMANN C L, KANAKASABAPATHY M K, THIRUMALARAJU P, et al. Performance of a deep learning based neural network in the selection of human blastocysts for implantation[J]. Elife,2020,9: e55301. doi:10.7554/elife.55301
8 LOEWKE K, CHO J H, BRUMAR C D, et al. Characterization of an artificial intelligence model for ranking static images of blastocyst stage embryos[J]. Fertil Steril, 2022,117(3): 528-535. doi:10.1016/j.fertnstert.2021.11.022
9 FITZ V W, KANAKASABAPATHY M K, THIRUMALARAJU P,et al. Should there be an “AI” in TEAM?Embryologists selection of high implantation potential embryos improves with the aid of an artificial intelligence algorithm[J]. J Assist Reprod Genet, 2021,38(10): 2663-2670. doi:10.1007/s10815-021-02318-7
10 UENO S, BERNTSEN J, ITO M, et al. Pregnancy prediction performance of an annotation-free embryo scoring system on the basis of deep learning after single vitrified-warmed blastocyst transfer: a single-center large cohort retrospective study[J]. Fertil Steril,2021,116(4): 1172-1180. doi:10.1016/j.fertnstert.2021.06.001
11 VERMILYEA M, HALL J M M, DIAKIW S M, et al. Development of an artificial intelligence-based assessment model for prediction of embryo viability using static images captured by optical light microscopy during IVF[J]. Hum Reprod, 2020,35(4): 770-784. doi:10.1093/humrep/deaa013
12 纪冰,马学工,李斌业,等. Time-lapse培养与常规培养卵裂期胚胎移植的妊娠及新生儿结局分析[J]. 实用医学杂志, 2020,36(21): 3001-3004. doi:10.3969/j.issn.1006-5725.2020.21.023
13 KRAGH M F, RIMESTAD J, BERNTSEN J, et al. Automatic grading of human blastocysts from time-lapse imaging[J]. Comput Biol Med, 2019,115: 103494. doi:10.1016/j.compbiomed.2019.103494
14 LEE C I, SU Y R, CHEN C H, et al. End-to-end deep learning for recognition of ploidy status using time-lapse videos[J]. J Assist Reprod Genet, 2021,38(7): 1655-1663. doi:10.1007/s10815-021-02228-8
15 HUANG T T F, KOSASA T, WALKER B, et al. Deep learning neural network analysis of human blastocyst expansion from time-lapse image files[J]. Reprod Biomed Online, 2021,42(6): 1075-1085. doi:10.1016/j.rbmo.2021.02.015
16 HUANG B, ZHENG S, MA B, et al. Using deep learning to predict the outcome of live birth from more than 10,000 embryo data[J]. BMC Pregnancy Childbirth, 2022,22(1): 36. doi:10.1186/s12884-021-04373-5
17 TRAN D, COOKE S, ILLINGWORTH P J, et al. Deep learning as a predictive tool for fetal heart pregnancy following time-lapse incubation and blastocyst transfer[J]. Hum Reprod, 2019,34(6): 1011-1018. doi:10.1093/humrep/dez064
18 DUVAL A, NOGUEIRA D, DISSLER N, et al. A hybrid artificial intelligence model leverages multi-centric clinical data to improve fetal heart rate pregnancy prediction across time-lapse systems[J]. Hum Reprod, 2023,38(4): 596-608. doi:10.1093/humrep/dead023
19 JIANG V S, KANDULA H, THIRUMALARAJU P, et al. The use of voting ensembles to improve the accuracy of deep neural networks as a non-invasive method to predict embryo ploidy status[J]. J Assist Reprod Genet, 2023,40(2): 301-308. doi:10.1007/s10815-022-02707-6
20 FIRUZINIA S, AFZALI S M, GHASEMIAN F, et al. A robust deep learning-based multiclass segmentation method for analyzing human metaphase II oocyte images[J]. Comput Methods Programs Biomed, 2021,201: 105946. doi:10.1016/j.cmpb.2021.105946
21 LIANG X, LIANG J, ZENG F, et al. Evaluation of oocyte maturity using artificial intelligence quantification of follicle volume biomarker by three-dimensional ultrasound[J]. Reprod Biomed Online, 2022,45(6): 1197-1206. doi:10.1016/j.rbmo.2022.07.012
22 JIANG V S, KARTIK D, THIRUMALARAJU P, et al. Advancements in the future of automating micromanipulation techniques in the IVF laboratory using deep convolutional neural networks[J]. J Assist Reprod Genet, 2023,40(2): 251-257. doi:10.1007/s10815-022-02685-9
23 杨静薇,邓成艳,黄学锋,等. 中华医学会生殖医学分会2019年度辅助生殖技术数据报告[J]. 生殖医学杂志, 2022,31(8):1015-1021.
24 CENTERS FOR DISEASE CONTROL AND PREVENTION. 2019 Assisted Reproductive Technology Fertility Clinicand National Summary Report[EB/OL]. .
25 LEE R, WITHERSPOON L, ROBINSON M, et al. Automated rare sperm identification from low-magnification microscopy images of dissociated microsurgical testicular sperm extraction samples using deep learning[J]. Fertil Steril, 2022,118(1): 90-99. doi:10.1016/j.fertnstert.2022.03.011
26 ABBASI A, MIAHI E, MIRROSHANDEL S A. Effect of deep transfer and multi-task learning on sperm abnormality detection[J]. Comput Biol Med, 2021,128: 104121. doi:10.1016/j.compbiomed.2020.104121
27 MARíN R, CHANG V. Impact of transfer learning for human sperm segmentation using deep learning[J]. Comput Biol Med,2021,136: 104687. doi:10.1016/j.compbiomed.2021.104687
28 RIORDON J, MCCALLUM C, SINTON D. Deep learning for the classification of human sperm[J]. Comput Biol Med, 2019,111: 103342. doi:10.1016/j.compbiomed.2019.103342
29 JAVADI S, MIRROSHANDEL S A. A novel deep learning method for automatic assessment of human sperm images[J]. Comput Biol Med, 2019,109: 182-194. doi:10.1016/j.compbiomed.2019.04.030
30 VALIU?KAIT? V, RAUDONIS V, MASKELIūNAS R, et al. Deep Learning Based Evaluation of Spermatozoid Motility for Artificial Insemination[J]. Sensors (Basel), 2020,21(1):72. doi:10.3390/s21010072
31 袁启龙,蒋满波,陆杉,等. 轻中度精索静脉曲张所致精子DNA碎片异常行保守干预对体外受精胚胎质量的影响[J]. 实用医学杂志,2020,36(12): 1644-1648. doi:10.3969/j.issn.1006-5725.2020.12.019
32 MCCALLUM C, RIORDON J, WANG Y, et al. Deep learning-based selection of human sperm with high DNA integrity[J]. Commun Biol, 2019,2: 250. doi:10.1038/s42003-019-0491-6
33 NOY L, BARNEA I, MIRSKY S K, et al. Sperm-cell DNA fragmentation prediction using label-free quantitative phase imaging and deep learning[J]. Cytometry A, 2023,103(6): 470-478. doi:10.1002/cyto.a.24703
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