收稿日期: 2023-08-23
网络出版日期: 2024-01-24
基金资助
上海市 2021 年度“科技创新行动计划”自然科学基金项目(21ZR1449400)
Research progress of the relationship between high fat diet-Induced gastrointestinal microbiota and gastrointestinal cancer
Received date: 2023-08-23
Online published: 2024-01-24
吴奇 , 卜乐 , 徐倍 . 高脂饮食引发胃肠菌群改变与胃肠肿瘤关系的研究进展[J]. 实用医学杂志, 2024 , 40(1) : 123 -128 . DOI: 10.3969/j.issn.1006-5725.2024.01.022
In healthy individuals， there is a favourable balance between commensal and potentially pathogenic bacteria. When the balance is broken， the host might suffer from gastrointestinal cancer. Studies have shown that high-fat diet can alter the composition of gastrointestinal microbiota，gastrointestinal microbiota may promote gastrointestinal cancer by affecting metabolites of gastrointestinal microbiota， leading to loss of gastrointestinal barrier function， suppressing anti-tumor immunity， etc. In this work， we will summary the current knowledge on relations and possible mechanisms of high-fat diet-associated gastrointestinal microbiota and gastrointestinal cancer. To provide new ideas for the treatment of gastrointestinal cancer.
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