高脂饮食引发胃肠菌群改变与胃肠肿瘤关系的研究进展

doi:10.3969/j.issn.1006-5725.2024.01.022

摘要/Abstract

摘要：

在健康个体中，胃肠道内有害菌、有益菌等处于共生平衡状态，其稳态的打破与胃肠肿瘤发生密切相关。研究表明高脂饮食引发胃肠菌群改变，失调的菌可能通过影响菌群代谢产物、导致胃肠屏障受损、抑制抗肿瘤免疫等方式促进胃肠肿瘤的发生发展。本文主要就高脂饮食引发胃肠菌群改变与胃肠肿瘤的关系；在高脂饮食介导下，菌群失调促进胃肠肿瘤发生发展的可能机制进行综述，以期为胃肠肿瘤治疗提供新思路。

关键词: 高脂饮食, 胃肠菌群, 胃肠肿瘤

Abstract:

In healthy individuals， there is a favourable balance between commensal and potentially pathogenic bacteria. When the balance is broken， the host might suffer from gastrointestinal cancer. Studies have shown that high-fat diet can alter the composition of gastrointestinal microbiota，gastrointestinal microbiota may promote gastrointestinal cancer by affecting metabolites of gastrointestinal microbiota， leading to loss of gastrointestinal barrier function， suppressing anti-tumor immunity， etc. In this work， we will summary the current knowledge on relations and possible mechanisms of high-fat diet-associated gastrointestinal microbiota and gastrointestinal cancer. To provide new ideas for the treatment of gastrointestinal cancer.

Key words: high fat diet, gastrointestinal microbiota, gastrointestinal cancer

中图分类号:

R589

吴奇,卜乐,徐倍. 高脂饮食引发胃肠菌群改变与胃肠肿瘤关系的研究进展[J]. 实用医学杂志, 2024, 40(1): 123-128.

Qi WU,Le BU,Bei. XU. Research progress of the relationship between high fat diet-Induced gastrointestinal microbiota and gastrointestinal cancer[J]. The Journal of Practical Medicine, 2024, 40(1): 123-128.

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