收稿日期: 2023-09-06
网络出版日期: 2023-12-19
基金资助
国家自然科学基金项目(82171656)
Song Emphasis on standardized clinical treatment of recurrent implant failure
Received date: 2023-09-06
Online published: 2023-12-19
反复种植失败（recurrent implantation failure， RIF）是指不孕症患者经历多个体外受精-胚胎移植（in vitro fertilization embryo transfer， IVF-ET）周期，并移植多枚优质胚胎而未获胚胎种植或临床妊娠。基于RIF的病因多而复杂，影响IVF-ET助孕结局的因素众多，目前国内外有关RIF的指南与共识，在RIF的定义、病因筛查、诊断与治疗等方面仍存在争议，为RIF在临床上的规范化诊治带来很大困惑。本文依据国内外指南与共识，结合近期相关研究进展，对RIF的临床上规范化诊治提出参考意见。
全松 , 王哲 . 重视体外受精-胚胎移植反复种植失败的规范化诊治[J]. 实用医学杂志, 2023 , 39(21) : 2693 -2697 . DOI: 10.3969/j.issn.1006-5725.2023.21.001
Recurrent implantation failure （RIF） refers to the situation where couples facing infertility undergo multiple IVF-ET cycles and transfer multiple high-quality embryos， yet are unable to achieve embryo implantation or clinical pregnancy. The causes of RIF are multifaceted and can be influenced by many factors that may impact the outcome of IVF-ET assisted pregnancy. Despite this， there is ongoing debate regarding the definition of RIF， as well as the screening， diagnosis， and treatment approaches. This confusion largely stems from differences between current domestic and foreign guidelines and consensus. In order to provide clarity on this issue， this article aims to offer reference opinions on the standardized clinical diagnosis and treatment of RIF， based on recent research progress as well as both domestic and foreign guidelines and consensus.
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